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PMC:7796041 / 24572-26166 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
746 492-500 Species denotes patients Tax:9606
747 616-624 Species denotes patients Tax:9606
748 816-824 Species denotes patients Tax:9606
749 1265-1273 Species denotes patients Tax:9606
750 1386-1394 Species denotes patients Tax:9606
751 681-699 Chemical denotes hydroxychloroquine MESH:D006886
752 704-716 Chemical denotes azithromycin MESH:D017963
753 983-1001 Chemical denotes hydroxychloroquine MESH:D006886
754 1062-1074 Chemical denotes azithromycin MESH:D017963
755 1404-1407 Chemical denotes QTc
756 33-43 Disease denotes arrhythmia MESH:D001145
757 81-89 Disease denotes COVID-19 MESH:C000657245
758 126-148 Disease denotes cardiovascular disease MESH:D002318
759 189-199 Disease denotes arrhythmia MESH:D001145
760 296-306 Disease denotes arrhythmia MESH:D001145
761 358-377 Disease denotes infectious diseases MESH:D003141
762 506-516 Disease denotes arrhythmia MESH:D001145
763 947-979 Disease denotes prolongation of the QTc interval MESH:D008133
764 1005-1013 Disease denotes COVID-19 MESH:C000657245
765 1124-1146 Disease denotes ventricular arrhythmia MESH:D001145
766 1201-1221 Disease denotes torsades des pointes MESH:D016171
767 1279-1302 Disease denotes ventricular arrhythmias MESH:D001145
768 1316-1338 Disease denotes cardiovascular disease MESH:D002318
769 1503-1526 Disease denotes ventricular arrhythmias MESH:D001145

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T177 33-43 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T178 126-148 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T179 189-199 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T180 296-306 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T181 506-516 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T182 1124-1146 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T183 1279-1302 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T184 1316-1338 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T185 1503-1526 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T204 0-200 Sentence denotes With respect to risk factors for arrhythmia incidence during hospitalization for COVID-19, we could identify age and previous cardiovascular disease as predictors for the occurrence of any arrhythmia.
T205 201-383 Sentence denotes These baseline characteristics have previously been shown to predispose for the development of arrhythmia in the general population without association with infectious diseases [24].
T206 384-488 Sentence denotes Thus, they may reflect a subgroup of greater general susceptibility to additional proarrhythmic effects.
T207 489-625 Sentence denotes In patients with arrhythmia in our cohort, QTc duration was longer at admission, albeit within normal range in the majority of patients.
T208 626-825 Sentence denotes Dynamic changes of the QTc interval under therapy with hydroxychloroquine and azithromycin cannot be evaluated as repeated ECGs during hospital stay were not systematically available in all patients.
T209 826-903 Sentence denotes Thus, proarrhythmic effects of these drugs cannot be excluded in this cohort.
T210 904-1091 Sentence denotes Previous reports point towards significant prolongation of the QTc interval by hydroxychloroquine in COVID-19 which is even more enhanced in combination with azithromycin therapy [25,26].
T211 1092-1177 Sentence denotes However, the rate of associated ventricular arrhythmia has been low in these studies.
T212 1178-1430 Sentence denotes Similarly, no typical “torsades des pointes” were seen in our cohort: in three of five patients with ventricular arrhythmias pre-existent cardiovascular disease was present, and only one of the remaining two patients received QTc-prolonging medication.
T213 1431-1594 Sentence denotes Thus, rather than induced by direct effects of administered medication, ventricular arrhythmias may have been due to other predisposing risk factors in our cohort.