PMC:7795966 / 3822-4443 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"MetHb is continuously produced under physiological conditions in a limited amount due to auto-oxidation, but it is rapidly converted back to Hb primarily by nicotinamide adenine dinucleotide (NADH)-dependent cytochrome-b5 reductase (also known as MetHb reductase) and to a limited degree also by ascorbate and glutathione [13]. COHb is formed when Hb and carbon monoxide (CO) interact; CO binds to heme molecules 240 times more than O2. The resulting COHb limits the blood’s O2-carrying capacity [14]. In healthy, non-smoking individuals, MetHb is in the range of 0.67 ± 0.33% [15] and COHb in the range of 0.5–1.5% [16].","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"154","span":{"begin":539,"end":544},"obj":"Gene"},{"id":"155","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"156","span":{"begin":157,"end":190},"obj":"Chemical"},{"id":"157","span":{"begin":192,"end":196},"obj":"Chemical"},{"id":"158","span":{"begin":296,"end":305},"obj":"Chemical"},{"id":"159","span":{"begin":310,"end":321},"obj":"Chemical"},{"id":"160","span":{"begin":355,"end":370},"obj":"Chemical"},{"id":"161","span":{"begin":372,"end":374},"obj":"Chemical"},{"id":"162","span":{"begin":386,"end":388},"obj":"Chemical"},{"id":"163","span":{"begin":398,"end":402},"obj":"Chemical"},{"id":"164","span":{"begin":433,"end":435},"obj":"Chemical"},{"id":"165","span":{"begin":475,"end":477},"obj":"Chemical"}],"attributes":[{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Gene:3048"},{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Gene:3048"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"MESH:D009243"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"MESH:D009243"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"MESH:D001205"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:D005978"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:D002248"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:D002248"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D002248"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D006418"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:D010100"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:D010100"},{"subj":"154","pred":"source","obj":"LitCovid-PubTator"},{"subj":"155","pred":"source","obj":"LitCovid-PubTator"},{"subj":"156","pred":"source","obj":"LitCovid-PubTator"},{"subj":"157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"160","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"},{"subj":"162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T25","span":{"begin":0,"end":327},"obj":"Sentence"},{"id":"T26","span":{"begin":328,"end":436},"obj":"Sentence"},{"id":"T27","span":{"begin":437,"end":501},"obj":"Sentence"},{"id":"T28","span":{"begin":502,"end":621},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ecdf","default":true},{"id":"LitCovid-sentences","color":"#ecc593"}]}]}}