PMC:7795966 / 22998-24092 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"Despite the obvious effect of oxidizing drugs on the formation of MetHb, it can also be formed as a byproduct of a physiological reaction in the form of an adaptive increased nitric oxide (NO) signaling due to an acute anemia [51]. Anemia can be associated with an infection and/or a systemic inflammatory reaction, termed “anemia of inflammation”, as part of the physiological reaction to the disease [52,53]. According to a study by Bellmann-Weiler et al. [54] on 259 hospitalized patients with COVID-19, 24.7% were anemic on admission, with the majority suffering from anemia of inflammation (68.8%). During hospitalization, the percentage of patients with anemia increased (around 68.8% at day 7). A significantly higher mortality during hospitalization was also found in those with anemia upon admission. Anemia is associated with an increased NO expression, leading to vasodilation and thus preventing tissue hypoxia, but also causing increased NO-based oxidation of Hb to MetHb [51]. Interestingly, anemia, and drops in total Hb (tHb), have been reported in COVID-19 patients 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