PMC:7795966 / 22998-24092 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
825	66-71	Gene	denotes	MetHb	Gene:3048
826	979-984	Gene	denotes	MetHb	Gene:3048
827	483-491	Species	denotes	patients	Tax:9606
828	646-654	Species	denotes	patients	Tax:9606
829	1074-1082	Species	denotes	patients	Tax:9606
830	175-187	Chemical	denotes	nitric oxide	MESH:D009569
831	1037-1040	Chemical	denotes	tHb
832	219-225	Disease	denotes	anemia	MESH:D000740
833	232-238	Disease	denotes	Anemia	MESH:D000740
834	265-274	Disease	denotes	infection	MESH:D007239
835	324-330	Disease	denotes	anemia	MESH:D000740
836	334-346	Disease	denotes	inflammation	MESH:D007249
837	497-505	Disease	denotes	COVID-19	MESH:C000657245
838	518-524	Disease	denotes	anemic	MESH:D000740
839	572-578	Disease	denotes	anemia	MESH:D000740
840	582-594	Disease	denotes	inflammation	MESH:D007249
841	660-666	Disease	denotes	anemia	MESH:D000740
842	725-734	Disease	denotes	mortality	MESH:D003643
843	787-793	Disease	denotes	anemia	MESH:D000740
844	810-816	Disease	denotes	Anemia	MESH:D000740
845	915-922	Disease	denotes	hypoxia	MESH:D000860
846	1006-1012	Disease	denotes	anemia	MESH:D000740
847	1065-1073	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue	hp_id
T44	219-225	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903
T45	232-238	Phenotype	denotes	Anemia	http://purl.obolibrary.org/obo/HP_0001903
T46	324-330	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903
T47	572-578	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903
T48	660-666	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903
T49	787-793	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903
T50	810-816	Phenotype	denotes	Anemia	http://purl.obolibrary.org/obo/HP_0001903
T51	915-922	Phenotype	denotes	hypoxia	http://purl.obolibrary.org/obo/HP_0012418
T52	1006-1012	Phenotype	denotes	anemia	http://purl.obolibrary.org/obo/HP_0001903

Id	Subject	Object	Predicate	Lexical cue
T177	0-231	Sentence	denotes	Despite the obvious effect of oxidizing drugs on the formation of MetHb, it can also be formed as a byproduct of a physiological reaction in the form of an adaptive increased nitric oxide (NO) signaling due to an acute anemia [51].
T178	232-410	Sentence	denotes	Anemia can be associated with an infection and/or a systemic inflammatory reaction, termed “anemia of inflammation”, as part of the physiological reaction to the disease [52,53].
T179	411-603	Sentence	denotes	According to a study by Bellmann-Weiler et al. [54] on 259 hospitalized patients with COVID-19, 24.7% were anemic on admission, with the majority suffering from anemia of inflammation (68.8%).
T180	604-701	Sentence	denotes	During hospitalization, the percentage of patients with anemia increased (around 68.8% at day 7).
T181	702-809	Sentence	denotes	A significantly higher mortality during hospitalization was also found in those with anemia upon admission.
T182	810-990	Sentence	denotes	Anemia is associated with an increased NO expression, leading to vasodilation and thus preventing tissue hypoxia, but also causing increased NO-based oxidation of Hb to MetHb [51].
T183	991-1094	Sentence	denotes	Interestingly, anemia, and drops in total Hb (tHb), have been reported in COVID-19 patients [22,55,56].