PMC:7795966 / 21889-22997 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"In the reports on MetHb and COVID-19 summarized in Section 3.2, the use of chloroquine or hydroxychloroquine is described. In the case reported by Kuipers et al. [17], the subject received chloroquine and had a G6PD deficiency; hydroxychloroquine was administered to the subject reported by Faisal et al. [20] (the G6PD status was not reported); and in the three cases reported by Naymagon et al. [18] all received hydroxychloroquine, while one subject was tested for G6PD deficiency and was positive. In the cases reported by Al-Aamri et al. [23] and Palmer et al. [22], the patients did not receive chloroquine and hydroxychloroquine, but the patient described by Al-Aamri et al. had a G6PD deficiency. A G6PD deficiency is not only relevant with respect to the reaction to antiviral oxidizing drugs, but also for the effects of the drug methylene blue administered to treat the methemoglobinemia. Methylene blue may be ineffective in patients with a G6PD deficiency since they lack sufficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) to reduce methylene blue to leuko-methylene 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