PMC:7795966 / 21889-22997 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
777	315-319	Gene	denotes	G6PD	Gene:2539
778	18-23	Gene	denotes	MetHb	Gene:3048
779	576-584	Species	denotes	patients	Tax:9606
780	645-652	Species	denotes	patient	Tax:9606
781	937-945	Species	denotes	patients	Tax:9606
782	75-86	Chemical	denotes	chloroquine	MESH:D002738
783	90-108	Chemical	denotes	hydroxychloroquine	MESH:D006886
784	189-200	Chemical	denotes	chloroquine	MESH:D002738
785	228-246	Chemical	denotes	hydroxychloroquine	MESH:D006886
786	415-433	Chemical	denotes	hydroxychloroquine	MESH:D006886
787	601-612	Chemical	denotes	chloroquine	MESH:D002738
788	617-635	Chemical	denotes	hydroxychloroquine	MESH:D006886
789	840-854	Chemical	denotes	methylene blue	MESH:D008751
790	900-914	Chemical	denotes	Methylene blue	MESH:D008751
791	1004-1047	Chemical	denotes	nicotinamide adenine dinucleotide phosphate	MESH:D009249
792	1049-1054	Chemical	denotes	NADPH	MESH:D009249
793	1066-1080	Chemical	denotes	methylene blue	MESH:D008751
794	1089-1099	Chemical	denotes	-methylene	MESH:C030011
795	28-36	Disease	denotes	COVID-19	MESH:C000657245
796	211-226	Disease	denotes	G6PD deficiency	MESH:D005955
797	468-483	Disease	denotes	G6PD deficiency	MESH:D005955
798	688-703	Disease	denotes	G6PD deficiency	MESH:D005955
799	707-722	Disease	denotes	G6PD deficiency	MESH:D005955
800	881-898	Disease	denotes	methemoglobinemia	MESH:D008708
801	953-968	Disease	denotes	G6PD deficiency	MESH:D005955

Id	Subject	Object	Predicate	Lexical cue	hp_id
T43	881-898	Phenotype	denotes	methemoglobinemia	http://purl.obolibrary.org/obo/HP_0012119

Id	Subject	Object	Predicate	Lexical cue
T172	0-122	Sentence	denotes	In the reports on MetHb and COVID-19 summarized in Section 3.2, the use of chloroquine or hydroxychloroquine is described.
T173	123-501	Sentence	denotes	In the case reported by Kuipers et al. [17], the subject received chloroquine and had a G6PD deficiency; hydroxychloroquine was administered to the subject reported by Faisal et al. [20] (the G6PD status was not reported); and in the three cases reported by Naymagon et al. [18] all received hydroxychloroquine, while one subject was tested for G6PD deficiency and was positive.
T174	502-704	Sentence	denotes	In the cases reported by Al-Aamri et al. [23] and Palmer et al. [22], the patients did not receive chloroquine and hydroxychloroquine, but the patient described by Al-Aamri et al. had a G6PD deficiency.
T175	705-899	Sentence	denotes	A G6PD deficiency is not only relevant with respect to the reaction to antiviral oxidizing drugs, but also for the effects of the drug methylene blue administered to treat the methemoglobinemia.
T176	900-1108	Sentence	denotes	Methylene blue may be ineffective in patients with a G6PD deficiency since they lack sufficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) to reduce methylene blue to leuko-methylene [49,50].