PMC:7795966 / 19812-20590 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
683	57-62	Gene	denotes	MetHb	Gene:3048
684	683-691	Species	denotes	patients	Tax:9606
685	249-260	Chemical	denotes	Chloroquine	MESH:D002738
686	380-391	Chemical	denotes	chloroquine	MESH:D002738
687	396-414	Chemical	denotes	hydroxychloroquine	MESH:D006886
688	432-443	Chemical	denotes	chloroquine	MESH:D002738
689	613-631	Chemical	denotes	hydroxychloroquine	MESH:D006886
690	198-215	Disease	denotes	methemoglobinemia	MESH:D008708
691	327-344	Disease	denotes	methemoglobinemia	MESH:D008708
692	473-481	Disease	denotes	COVID-19	MESH:C000657245
693	670-679	Disease	denotes	mortality	MESH:D003643
694	710-718	Disease	denotes	COVID-19	MESH:C000657245
695	769-777	Disease	denotes	COVID-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue	hp_id
T37	198-215	Phenotype	denotes	methemoglobinemia	http://purl.obolibrary.org/obo/HP_0012119
T38	327-344	Phenotype	denotes	methemoglobinemia	http://purl.obolibrary.org/obo/HP_0012119

Id	Subject	Object	Predicate	Lexical cue
T159	0-115	Sentence	denotes	It is well known that several medical drugs can increase MetHb concentration in the blood as a side-effect [26,27].
T160	116-248	Sentence	denotes	A recent review reports the early recognition, pathophysiology, and management of methemoglobinemia in the intensive care unit [28].
T161	249-374	Sentence	denotes	Chloroquine is such a drug for which reports were published regarding induced methemoglobinemia due to its intake [29,30,31].
T162	375-570	Sentence	denotes	Both chloroquine and hydroxychloroquine (a derivative of chloroquine) are currently used to treat COVID-19, while debate is ongoing about their effectiveness and safety [32,33,34,35,36,37,38,39].
T163	571-778	Sentence	denotes	Moderately certain evidence suggests that hydroxychloroquine lacks efficacy in reducing short-term mortality in patients hospitalized with COVID-19 or at risk of hospitalization in outpatients with COVID-19.