PMC:7795966 / 16740-17894 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"603","span":{"begin":429,"end":434},"obj":"Gene"},{"id":"604","span":{"begin":1089,"end":1094},"obj":"Gene"},{"id":"605","span":{"begin":1036,"end":1041},"obj":"Gene"},{"id":"606","span":{"begin":884,"end":889},"obj":"Gene"},{"id":"607","span":{"begin":782,"end":787},"obj":"Gene"},{"id":"608","span":{"begin":664,"end":669},"obj":"Gene"},{"id":"609","span":{"begin":394,"end":399},"obj":"Gene"},{"id":"610","span":{"begin":55,"end":60},"obj":"Gene"},{"id":"611","span":{"begin":9,"end":17},"obj":"Species"},{"id":"612","span":{"begin":295,"end":303},"obj":"Species"},{"id":"613","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"614","span":{"begin":286,"end":294},"obj":"Disease"},{"id":"615","span":{"begin":484,"end":492},"obj":"Disease"}],"attributes":[{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"Gene:3048"},{"id":"A604","pred":"tao:has_database_id","subj":"604","obj":"Gene:3048"},{"id":"A605","pred":"tao:has_database_id","subj":"605","obj":"Gene:3048"},{"id":"A606","pred":"tao:has_database_id","subj":"606","obj":"Gene:3048"},{"id":"A607","pred":"tao:has_database_id","subj":"607","obj":"Gene:3048"},{"id":"A608","pred":"tao:has_database_id","subj":"608","obj":"Gene:3048"},{"id":"A609","pred":"tao:has_database_id","subj":"609","obj":"Gene:3048"},{"id":"A610","pred":"tao:has_database_id","subj":"610","obj":"Gene:3048"},{"id":"A611","pred":"tao:has_database_id","subj":"611","obj":"Tax:9606"},{"id":"A612","pred":"tao:has_database_id","subj":"612","obj":"Tax:9606"},{"id":"A613","pred":"tao:has_database_id","subj":"613","obj":"MESH:C000657245"},{"id":"A614","pred":"tao:has_database_id","subj":"614","obj":"MESH:C000657245"},{"id":"A615","pred":"tao:has_database_id","subj":"615","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"COVID-19 patients (n = 25) were shown to have a higher MetHb compared to healthy individuals (n = 25) as demonstrated in a cross-sectional study by Alamdari et al. [21], supporting the findings reported. However, the cross-sectional study of Soltan et al. [19] with a large cohort (534 COVID-19 patients and 114,957 pre-pandemic controls) showed no statistically significant differences in the MetHb values despite the fact that MetHb was an important parameter for the prediction of COVID-19 based on the algorithm the group developed. This apparent discrepancy between the result of Alamdari et al. and Soltan et al. seems to be due to the following reason: the MetHb data used by Soltan et al. stem from the time of emergency presentations and admission to hospital, whereas the MetHb data from Alamdari et al. were collected from the whole time-course of the hospital stay. Since MetHb has been reported to increase during the development of the disease [18,20,22], the results of Soltan et al. are understandable since, during the MetHb sampling time at the beginning of the disease, MetHb is not necessarily increased (at least at the group level)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T140","span":{"begin":0,"end":203},"obj":"Sentence"},{"id":"T141","span":{"begin":204,"end":536},"obj":"Sentence"},{"id":"T142","span":{"begin":537,"end":877},"obj":"Sentence"},{"id":"T143","span":{"begin":878,"end":1154},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COVID-19 patients (n = 25) were shown to have a higher MetHb compared to healthy individuals (n = 25) as demonstrated in a cross-sectional study by Alamdari et al. [21], supporting the findings reported. However, the cross-sectional study of Soltan et al. [19] with a large cohort (534 COVID-19 patients and 114,957 pre-pandemic controls) showed no statistically significant differences in the MetHb values despite the fact that MetHb was an important parameter for the prediction of COVID-19 based on the algorithm the group developed. This apparent discrepancy between the result of Alamdari et al. and Soltan et al. seems to be due to the following reason: the MetHb data used by Soltan et al. stem from the time of emergency presentations and admission to hospital, whereas the MetHb data from Alamdari et al. were collected from the whole time-course of the hospital stay. Since MetHb has been reported to increase during the development of the disease [18,20,22], the results of Soltan et al. are understandable since, during the MetHb sampling time at the beginning of the disease, MetHb is not necessarily increased (at least at the group level)."}