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PMC:7795856 / 3117-5187 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
113 34-37 Gene denotes Tα1 Gene:134864
114 372-375 Gene denotes Tα1 Gene:134864
115 583-586 Gene denotes Tα1 Gene:134864
116 911-914 Gene denotes Tα1 Gene:134864
117 965-971 Gene denotes CTLA-4 Gene:1493
118 1044-1047 Gene denotes Tα1 Gene:20539
119 1115-1121 Gene denotes CTLA-4 Gene:12477
120 1456-1459 Gene denotes Tα1 Gene:20539
121 1617-1620 Gene denotes Tα1 Gene:20539
122 1747-1750 Gene denotes Tα1 Gene:134864
123 1801-1807 Gene denotes hIFN-α Gene:3439
124 1937-1940 Gene denotes Tα1 Gene:134864
125 879-887 Species denotes patients Tax:9606
126 1094-1100 Species denotes murine Tax:10090
127 1781-1786 Species denotes human Tax:9606
128 1914-1922 Species denotes patients Tax:9606
129 223-226 Species denotes HBV Tax:10407
130 250-253 Species denotes HCV Tax:11103
131 951-961 Chemical denotes ipilimumab MESH:D000074324
132 1003-1013 Chemical denotes ipilimumab MESH:D000074324
133 202-221 Disease denotes chronic hepatitis B MESH:D019694
134 229-248 Disease denotes chronic hepatitis C MESH:D019698
135 437-443 Disease denotes cancer MESH:D009369
136 608-619 Disease denotes cold tumors MESH:D000067390
137 710-716 Disease denotes tumors MESH:D009369
138 870-878 Disease denotes melanoma MESH:D008545
139 1069-1088 Disease denotes intestinal toxicity MESH:D007410
140 1130-1137 Disease denotes colitis MESH:D003092
141 1268-1283 Disease denotes cystic fibrosis MESH:D003550
142 1290-1308 Disease denotes multiple sclerosis MESH:D009103
143 1319-1325 Disease denotes sepsis MESH:D018805
144 1437-1445 Disease denotes COVID-19 MESH:C000657245
145 1524-1532 Disease denotes COVID-19 MESH:C000657245
146 1576-1582 Disease denotes sepsis MESH:D018805
147 1702-1710 Disease denotes COVID-19 MESH:C000657245
148 1711-1720 Disease denotes infection MESH:D007239
149 1967-1976 Disease denotes mortality MESH:D003643
150 1987-1995 Disease denotes COVID-19 MESH:C000657245
151 2014-2029 Disease denotes lymphocytopenia MESH:D008231

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 202-219 Phenotype denotes chronic hepatitis http://purl.obolibrary.org/obo/HP_0200123
T8 229-246 Phenotype denotes chronic hepatitis http://purl.obolibrary.org/obo/HP_0200123
T9 437-443 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T10 870-878 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861
T11 1130-1137 Phenotype denotes colitis http://purl.obolibrary.org/obo/HP_0002583
T12 1319-1325 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T13 1576-1582 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T14 2014-2029 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T22 0-148 Sentence denotes In fact, a chemically synthesized Tα1 peptide drug has been marketed for more than 20 years under the trade name Zadaxin™ in more than 30 countries.
T23 149-351 Sentence denotes Zadaxin™ is clinically approved for the treatment of chronic hepatitis B (HBV), chronic hepatitis C (HCV), as a vaccine adjuvant, and as adjuvant therapy for chemotherapy-induced immune suppression [7].
T24 352-543 Sentence denotes Of note, the use of Tα1 has recently undergone reassessment in the context of modern cancer immunotherapies, as there is indication that this peptide may support immune checkpoint inhibition.
T25 544-761 Sentence denotes Preclinical data provide evidence that Tα1 transforms so called cold tumors, which poorly respond to immune checkpoint inhibitors, into highly lymphocyte-infiltrated tumors and, thus, boosts therapeutic efficacy [15].
T26 762-1033 Sentence denotes Indeed, a retrospective study evaluating clinical phase II data reported an increase in overall survival of melanoma patients receiving sequentially Tα1 and the immune checkpoint inhibitor ipilimumab, a CTLA-4-blocking antibody, compared to ipilimumab therapy alone [16].
T27 1034-1225 Sentence denotes Moreover, Tα1 was shown to prevent intestinal toxicity in a murine model of anti-CTLA-4-induced colitis, hence contributing to an improved safety profile of immune checkpoint inhibitors [17].
T28 1226-1402 Sentence denotes Beyond that, emerging indications such as cystic fibrosis [18], multiple sclerosis [19], and sepsis [20] further emphasize the huge potential of this small therapeutic peptide.
T29 1403-1502 Sentence denotes Finally, with the outbreak of the COVID-19 pandemic, Tα1 recently gained new attention in virology.
T30 1503-1636 Sentence denotes Clinical symptoms of COVID-19 to some extent resemble a pathogen-induced sepsis, which justifies immunomodulatory Tα1 treatment [21].
T31 1637-1852 Sentence denotes Along these lines, Chinese medical staff members at high risk of COVID-19 infection already received a weekly Tα1 injection in combination with human interferon 1 (hIFN-α) nasal drops as a prophylactic measure [22].
T32 1853-2070 Sentence denotes Furthermore, a recent retrospective study in treated Chinese patients revealed that Tα1 significantly reduced the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells [23].