PMC:7795856 / 21484-21801 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"366","span":{"begin":229,"end":251},"obj":"Gene"},{"id":"367","span":{"begin":253,"end":259},"obj":"Gene"},{"id":"368","span":{"begin":299,"end":304},"obj":"Gene"}],"attributes":[{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"Gene:1803"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"Gene:1803"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"Gene:2641"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"]. The approach described here, N- or C-terminal PASylation, optionally combined with acetylation, solves both. On the one hand, N-terminal acetylation protects peptides from proteolytic degradation by exoproteases, for example, dipeptidyl peptidase-4 (DPP-IV), as shown for N-terminally acetylated GLP-1 [68]. On the"}

{"project":"LitCovid-sentences","denotations":[{"id":"T121","span":{"begin":3,"end":111},"obj":"Sentence"},{"id":"T122","span":{"begin":112,"end":310},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"]. The approach described here, N- or C-terminal PASylation, optionally combined with acetylation, solves both. On the one hand, N-terminal acetylation protects peptides from proteolytic degradation by exoproteases, for example, dipeptidyl peptidase-4 (DPP-IV), as shown for N-terminally acetylated GLP-1 [68]. On the"}