PMC:7795856 / 19950-20692 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795856","sourcedb":"PMC","sourceid":"7795856","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795856","text":"Moreover, a more continuous plasma level above the minimum effective dose due to slower clearance, as illustrated by the drastically increased AUC, should boost in vivo efficacy and open new treatment perspectives. Especially in preclinical animal models, which typically suffer from a much quicker drug clearance compared to humans [37] owing to their smaller body size, a long-acting Tα1 should lead to more convincing pharmacodynamic (PD) effects and pave the way for biopharmaceutical development for novel indications such as cystic fibrosis [18], HIV-1 infection [58], sepsis [20], or cancer [59]. For example, cancer studies have demonstrated that high doses of the conventional peptide are required to achieve antitumor activity [60].","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"340","span":{"begin":386,"end":389},"obj":"Gene"},{"id":"341","span":{"begin":326,"end":332},"obj":"Species"},{"id":"342","span":{"begin":438,"end":440},"obj":"Disease"},{"id":"343","span":{"begin":531,"end":546},"obj":"Disease"},{"id":"347","span":{"begin":617,"end":623},"obj":"Disease"}],"attributes":[{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"Gene:134864"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"Tax:9606"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"MESH:D010300"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:D003550"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"MESH:D009369"},{"subj":"340","pred":"source","obj":"LitCovid-PubTator"},{"subj":"341","pred":"source","obj":"LitCovid-PubTator"},{"subj":"342","pred":"source","obj":"LitCovid-PubTator"},{"subj":"343","pred":"source","obj":"LitCovid-PubTator"},{"subj":"347","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":575,"end":581},"obj":"Phenotype"},{"id":"T19","span":{"begin":591,"end":597},"obj":"Phenotype"},{"id":"T20","span":{"begin":617,"end":623},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0100806"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A20","pred":"hp_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T114","span":{"begin":0,"end":214},"obj":"Sentence"},{"id":"T115","span":{"begin":215,"end":603},"obj":"Sentence"},{"id":"T116","span":{"begin":604,"end":742},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T114","pred":"source","obj":"LitCovid-sentences"},{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ecbb","default":true},{"id":"LitCovid-PD-HP","color":"#eca193"},{"id":"LitCovid-sentences","color":"#939eec"}]}]}}