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PMC:7795856 / 19950-20692 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
340 386-389 Gene denotes Tα1 Gene:134864
341 326-332 Species denotes humans Tax:9606
342 438-440 Disease denotes PD MESH:D010300
343 531-546 Disease denotes cystic fibrosis MESH:D003550
347 617-623 Disease denotes cancer MESH:D009369

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 575-581 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T19 591-597 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T20 617-623 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T114 0-214 Sentence denotes Moreover, a more continuous plasma level above the minimum effective dose due to slower clearance, as illustrated by the drastically increased AUC, should boost in vivo efficacy and open new treatment perspectives.
T115 215-603 Sentence denotes Especially in preclinical animal models, which typically suffer from a much quicker drug clearance compared to humans [37] owing to their smaller body size, a long-acting Tα1 should lead to more convincing pharmacodynamic (PD) effects and pave the way for biopharmaceutical development for novel indications such as cystic fibrosis [18], HIV-1 infection [58], sepsis [20], or cancer [59].
T116 604-742 Sentence denotes For example, cancer studies have demonstrated that high doses of the conventional peptide are required to achieve antitumor activity [60].