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PMC:7784834 / 8333-9483 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
156 844-849 Gene denotes spike Gene:43740568
157 833-843 Species denotes SARS-CoV-2 Tax:2697049
158 59-68 Chemical denotes remdesvir
159 70-79 Chemical denotes ribavirin MESH:D012254
160 81-92 Chemical denotes favipiravir MESH:C462182
161 94-105 Chemical denotes chloroquine MESH:D002738
162 107-125 Chemical denotes hydroxychloroquine MESH:D006886
163 127-138 Chemical denotes oseltamivir MESH:D053139
164 143-153 Chemical denotes umifenovir MESH:C086979
165 189-199 Chemical denotes toclizumab
166 236-248 Chemical denotes azithromycin MESH:D017963
167 300-308 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T52 0-309 Sentence denotes Many pharmacological agents such as antiviral agent’s viz. remdesvir, ribavirin, favipiravir, chloroquine, hydroxychloroquine, oseltamivir and umifenovir; immunomodulatory agents including toclizumab, inteferons; adjunctive agents like azithromycin, corticosteroids have been repurposed for treating COVID-19.
T53 310-429 Sentence denotes However, so far no therapy has been (Lam et al., 2020) recognized as an effective treatment against the deadly disease.
T54 430-592 Sentence denotes It has, therefore, become the need of the hour to adopt computational approaches for drug discovery and repurpose other existing marketed drugs for its treatment.
T55 593-706 Sentence denotes Drug repurposing via high-throughput screening of various databases is a cost-effective and time-saving approach.
T56 707-876 Sentence denotes The present report pertains to the above-described drug discovery effort using a repurposing screening strategy to target the SARS-CoV-2 spike protein and main protease.
T57 877-1150 Sentence denotes Together, these proteins play a key role in binding to host cell receptors and causing fusion to render viral entry, determining the host range and tissue tropism, eliciting an immune response by the host, viral replication, transcription and protein processing (Li, 2016).