PMC:7784834 / 8333-9483 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784834","sourcedb":"PMC","sourceid":"7784834","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784834","text":"Many pharmacological agents such as antiviral agent’s viz. remdesvir, ribavirin, favipiravir, chloroquine, hydroxychloroquine, oseltamivir and umifenovir; immunomodulatory agents including toclizumab, inteferons; adjunctive agents like azithromycin, corticosteroids have been repurposed for treating COVID-19. However, so far no therapy has been (Lam et al., 2020) recognized as an effective treatment against the deadly disease. It has, therefore, become the need of the hour to adopt computational approaches for drug discovery and repurpose other existing marketed drugs for its treatment. Drug repurposing via high-throughput screening of various databases is a cost-effective and time-saving approach. The present report pertains to the above-described drug discovery effort using a repurposing screening strategy to target the SARS-CoV-2 spike protein and main protease. Together, these proteins play a key role in binding to host cell receptors and causing fusion to render viral entry, determining the host range and tissue tropism, eliciting an immune response by the host, viral replication, transcription and protein processing (Li, 2016).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"156","span":{"begin":844,"end":849},"obj":"Gene"},{"id":"157","span":{"begin":833,"end":843},"obj":"Species"},{"id":"158","span":{"begin":59,"end":68},"obj":"Chemical"},{"id":"159","span":{"begin":70,"end":79},"obj":"Chemical"},{"id":"160","span":{"begin":81,"end":92},"obj":"Chemical"},{"id":"161","span":{"begin":94,"end":105},"obj":"Chemical"},{"id":"162","span":{"begin":107,"end":125},"obj":"Chemical"},{"id":"163","span":{"begin":127,"end":138},"obj":"Chemical"},{"id":"164","span":{"begin":143,"end":153},"obj":"Chemical"},{"id":"165","span":{"begin":189,"end":199},"obj":"Chemical"},{"id":"166","span":{"begin":236,"end":248},"obj":"Chemical"},{"id":"167","span":{"begin":300,"end":308},"obj":"Disease"}],"attributes":[{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:43740568"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Tax:2697049"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:D012254"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:C462182"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:D002738"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D006886"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D053139"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:C086979"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"MESH:D017963"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"MESH:C000657245"},{"subj":"156","pred":"source","obj":"LitCovid-PubTator"},{"subj":"157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"160","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"},{"subj":"162","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"167","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T52","span":{"begin":0,"end":309},"obj":"Sentence"},{"id":"T53","span":{"begin":310,"end":429},"obj":"Sentence"},{"id":"T54","span":{"begin":430,"end":592},"obj":"Sentence"},{"id":"T55","span":{"begin":593,"end":706},"obj":"Sentence"},{"id":"T56","span":{"begin":707,"end":876},"obj":"Sentence"},{"id":"T57","span":{"begin":877,"end":1150},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93c3","default":true},{"id":"LitCovid-sentences","color":"#93deec"}]}]}}