PMC:7784829 / 5615-6043 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T43","span":{"begin":0,"end":116},"obj":"Sentence"},{"id":"T44","span":{"begin":117,"end":278},"obj":"Sentence"},{"id":"T45","span":{"begin":279,"end":428},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We found that curcumin and few of its derivatives showed promising results to be potential spike protein inhibitors. One of the derivatives, bis-demethoxycurcumin, showed the best binding affinity to the spike protein of both the SARS-CoV and the novel corona virus, SARS-CoV-2. The possibility for few of the curcumin derivatives, that showed good binding affinity, could be tested for further therapeutic use against COVID-19."}

{"project":"LitCovid-PubTator","denotations":[{"id":"155","span":{"begin":204,"end":209},"obj":"Gene"},{"id":"156","span":{"begin":91,"end":96},"obj":"Gene"},{"id":"157","span":{"begin":230,"end":238},"obj":"Species"},{"id":"158","span":{"begin":247,"end":265},"obj":"Species"},{"id":"159","span":{"begin":267,"end":277},"obj":"Species"},{"id":"160","span":{"begin":14,"end":22},"obj":"Chemical"},{"id":"161","span":{"begin":141,"end":162},"obj":"Chemical"},{"id":"162","span":{"begin":310,"end":318},"obj":"Chemical"},{"id":"163","span":{"begin":419,"end":427},"obj":"Disease"}],"attributes":[{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Gene:43740568"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Gene:43740568"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Tax:694009"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"Tax:2697049"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"Tax:2697049"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:D003474"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:C034786"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D003474"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We found that curcumin and few of its derivatives showed promising results to be potential spike protein inhibitors. One of the derivatives, bis-demethoxycurcumin, showed the best binding affinity to the spike protein of both the SARS-CoV and the novel corona virus, SARS-CoV-2. The possibility for few of the curcumin derivatives, that showed good binding affinity, could be tested for further therapeutic use against COVID-19."}