PMC:7784829 / 27756-28418 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":287,"end":293},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Curcumin has earlier shown to have specific inhibitory effect on the NA activity in influenza virus (Chen et al., 2013; Richart et al., 2018) and modulating immune response to prevent injury to the lung tissue (Han et al., 2018). Till date, Bis-demethoxy curcumin has shown to have anti-cancer and hepato-protective activities (Kumaravel et al., 2013; Rajagopalan et al., 2010). This is the first time; it is predicted to have a potential anti-viral activity. Therefore, these curcumin derivatives, which have been predicted to bind to the SARS-CoV-2 spike protein, could be explored as probable inhibitors of COVID-19 spike protein through experimental studies."}

{"project":"LitCovid-sentences","denotations":[{"id":"T300","span":{"begin":0,"end":229},"obj":"Sentence"},{"id":"T301","span":{"begin":230,"end":378},"obj":"Sentence"},{"id":"T302","span":{"begin":379,"end":459},"obj":"Sentence"},{"id":"T303","span":{"begin":460,"end":662},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Curcumin has earlier shown to have specific inhibitory effect on the NA activity in influenza virus (Chen et al., 2013; Richart et al., 2018) and modulating immune response to prevent injury to the lung tissue (Han et al., 2018). Till date, Bis-demethoxy curcumin has shown to have anti-cancer and hepato-protective activities (Kumaravel et al., 2013; Rajagopalan et al., 2010). This is the first time; it is predicted to have a potential anti-viral activity. Therefore, these curcumin derivatives, which have been predicted to bind to the SARS-CoV-2 spike protein, could be explored as probable inhibitors of COVID-19 spike protein through experimental studies."}

{"project":"LitCovid-PubTator","denotations":[{"id":"751","span":{"begin":551,"end":556},"obj":"Gene"},{"id":"752","span":{"begin":619,"end":624},"obj":"Gene"},{"id":"753","span":{"begin":84,"end":99},"obj":"Species"},{"id":"754","span":{"begin":540,"end":550},"obj":"Species"},{"id":"755","span":{"begin":0,"end":8},"obj":"Chemical"},{"id":"756","span":{"begin":241,"end":263},"obj":"Chemical"},{"id":"757","span":{"begin":477,"end":485},"obj":"Chemical"},{"id":"758","span":{"begin":287,"end":293},"obj":"Disease"},{"id":"759","span":{"begin":610,"end":618},"obj":"Disease"}],"attributes":[{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:43740568"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:43740568"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Tax:11308"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Tax:2697049"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"MESH:D003474"},{"id":"A756","pred":"tao:has_database_id","subj":"756","obj":"MESH:C034786"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"MESH:D003474"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"MESH:D009369"},{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Curcumin has earlier shown to have specific inhibitory effect on the NA activity in influenza virus (Chen et al., 2013; Richart et al., 2018) and modulating immune response to prevent injury to the lung tissue (Han et al., 2018). Till date, Bis-demethoxy curcumin has shown to have anti-cancer and hepato-protective activities (Kumaravel et al., 2013; Rajagopalan et al., 2010). This is the first time; it is predicted to have a potential anti-viral activity. Therefore, these curcumin derivatives, which have been predicted to bind to the SARS-CoV-2 spike protein, could be explored as probable inhibitors of COVID-19 spike protein through experimental studies."}