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PMC:7784829 / 26388-28418 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 1655-1661 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T291 0-25 Sentence denotes Conclusion and discussion
T292 26-122 Sentence denotes The spike proteins of corona viruses are essential for entry of the virus into the target cells.
T293 123-291 Sentence denotes The spike protein exists as a trimer on the surface of the virus with one of the monomer in up conformation and the other two in down conformation (Wrapp et al., 2020).
T294 292-433 Sentence denotes The N-terminal region (S1) of the S protein is important for binding to the cellular receptor ACE2 (Hoffmann et al., 2020; Tai et al., 2020).
T295 434-610 Sentence denotes The S protein undergoes priming by cellular protease, TMPRSS2 and the S2 region of the protein is responsible for fusion of viral and cellular membrane (Hoffmann et al., 2020).
T296 611-770 Sentence denotes Therefore, identifying therapeutics for the S protein of the novel corona virus could potentially target the critical process of entry and fusion of the virus.
T297 771-886 Sentence denotes Curcumin and its derivatives are known for their many biological activities, one of them is its antiviral activity.
T298 887-1017 Sentence denotes Therefore, here, we examined the potential of curcumin, and its derivatives, to bind to the SARS-CoV and SARS-CoV-2 spike protein.
T299 1018-1367 Sentence denotes From our computational molecular docking approach (using auto dock 4.2, PDB ID - 6CRV, 6M0J) and in-silico ADMET tool, we predicted that Bis-demethoxy curcumin, compound-4 and compound-2 were the most recommended curcumin compounds which bind to RBD domain of the SARS-CoV-2 Spike protein and SARS-CoV spike protein efficiently in in silico studies.
T300 1368-1597 Sentence denotes Curcumin has earlier shown to have specific inhibitory effect on the NA activity in influenza virus (Chen et al., 2013; Richart et al., 2018) and modulating immune response to prevent injury to the lung tissue (Han et al., 2018).
T301 1598-1746 Sentence denotes Till date, Bis-demethoxy curcumin has shown to have anti-cancer and hepato-protective activities (Kumaravel et al., 2013; Rajagopalan et al., 2010).
T302 1747-1827 Sentence denotes This is the first time; it is predicted to have a potential anti-viral activity.
T303 1828-2030 Sentence denotes Therefore, these curcumin derivatives, which have been predicted to bind to the SARS-CoV-2 spike protein, could be explored as probable inhibitors of COVID-19 spike protein through experimental studies.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
715 127-132 Gene denotes spike Gene:43740568
716 386-390 Gene denotes ACE2 Gene:59272
717 488-495 Gene denotes TMPRSS2 Gene:7113
718 30-35 Gene denotes spike Gene:43740568
719 672-690 Species denotes novel corona virus Tax:2697049
731 1003-1008 Gene denotes spike Gene:43740568
732 1293-1298 Gene denotes Spike Gene:43740568
733 1320-1325 Gene denotes spike Gene:43740568
734 979-987 Species denotes SARS-CoV Tax:694009
735 992-1002 Species denotes SARS-CoV-2 Tax:2697049
736 1282-1292 Species denotes SARS-CoV-2 Tax:2697049
737 1311-1319 Species denotes SARS-CoV Tax:694009
738 771-779 Chemical denotes Curcumin MESH:D003474
739 933-941 Chemical denotes curcumin MESH:D003474
740 1155-1177 Chemical denotes Bis-demethoxy curcumin MESH:C034786
741 1231-1239 Chemical denotes curcumin MESH:D003474
751 1919-1924 Gene denotes spike Gene:43740568
752 1987-1992 Gene denotes spike Gene:43740568
753 1452-1467 Species denotes influenza virus Tax:11308
754 1908-1918 Species denotes SARS-CoV-2 Tax:2697049
755 1368-1376 Chemical denotes Curcumin MESH:D003474
756 1609-1631 Chemical denotes Bis-demethoxy curcumin MESH:C034786
757 1845-1853 Chemical denotes curcumin MESH:D003474
758 1655-1661 Disease denotes cancer MESH:D009369
759 1978-1986 Disease denotes COVID-19 MESH:C000657245