PMC:7784829 / 23424-26386 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T253","span":{"begin":0,"end":8},"obj":"Sentence"},{"id":"T254","span":{"begin":10,"end":64},"obj":"Sentence"},{"id":"T255","span":{"begin":65,"end":118},"obj":"Sentence"},{"id":"T256","span":{"begin":119,"end":186},"obj":"Sentence"},{"id":"T257","span":{"begin":187,"end":274},"obj":"Sentence"},{"id":"T258","span":{"begin":275,"end":360},"obj":"Sentence"},{"id":"T259","span":{"begin":361,"end":447},"obj":"Sentence"},{"id":"T260","span":{"begin":448,"end":529},"obj":"Sentence"},{"id":"T261","span":{"begin":530,"end":613},"obj":"Sentence"},{"id":"T262","span":{"begin":614,"end":697},"obj":"Sentence"},{"id":"T263","span":{"begin":698,"end":777},"obj":"Sentence"},{"id":"T264","span":{"begin":778,"end":857},"obj":"Sentence"},{"id":"T265","span":{"begin":858,"end":937},"obj":"Sentence"},{"id":"T266","span":{"begin":938,"end":1017},"obj":"Sentence"},{"id":"T267","span":{"begin":1018,"end":1095},"obj":"Sentence"},{"id":"T268","span":{"begin":1096,"end":1174},"obj":"Sentence"},{"id":"T269","span":{"begin":1175,"end":1256},"obj":"Sentence"},{"id":"T270","span":{"begin":1257,"end":1335},"obj":"Sentence"},{"id":"T271","span":{"begin":1336,"end":1416},"obj":"Sentence"},{"id":"T272","span":{"begin":1417,"end":1499},"obj":"Sentence"},{"id":"T273","span":{"begin":1500,"end":1583},"obj":"Sentence"},{"id":"T274","span":{"begin":1584,"end":1666},"obj":"Sentence"},{"id":"T275","span":{"begin":1667,"end":1750},"obj":"Sentence"},{"id":"T276","span":{"begin":1751,"end":1836},"obj":"Sentence"},{"id":"T277","span":{"begin":1837,"end":1924},"obj":"Sentence"},{"id":"T278","span":{"begin":1925,"end":2010},"obj":"Sentence"},{"id":"T279","span":{"begin":2011,"end":2096},"obj":"Sentence"},{"id":"T280","span":{"begin":2097,"end":2181},"obj":"Sentence"},{"id":"T281","span":{"begin":2182,"end":2699},"obj":"Sentence"},{"id":"T282","span":{"begin":2700,"end":2705},"obj":"Sentence"},{"id":"T283","span":{"begin":2706,"end":2760},"obj":"Sentence"},{"id":"T284","span":{"begin":2761,"end":2803},"obj":"Sentence"},{"id":"T285","span":{"begin":2804,"end":2832},"obj":"Sentence"},{"id":"T286","span":{"begin":2833,"end":2857},"obj":"Sentence"},{"id":"T287","span":{"begin":2858,"end":2885},"obj":"Sentence"},{"id":"T288","span":{"begin":2886,"end":2910},"obj":"Sentence"},{"id":"T289","span":{"begin":2911,"end":2937},"obj":"Sentence"},{"id":"T290","span":{"begin":2938,"end":2962},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 5. In-silico ADME prediction for curcumin derivatives[a].\nComp Absorption Distribution Metabolism Excretion\n  WS CP IA SP PI-1 PI-2 VD FU BBB CNS CI-1 CI-2 TC RS\nBHBC –2.91 0.67 88.62 –2.73 Yes Yes –0.39 0.31 –0.67 –0.85 No Yes 0.15 No\nMNC –3.64 0.43 100 –2.73 Yes Yes –1.45 0.33 –0.39 –2.73 Yes Yes 0.26 No\nBDMC –4.43 1.01 95.92 –2.99 No No –0.22 0.08 –0.72 –2.11 Yes Yes 0.12 No\n1 –4.66 1.25 91.80 –2.51 No No 0.18 0.06 0.01 –1.45 Yes Yes 0.10 No\n2 –3.23 0.93 89.16 –2.76 No No –0.07 0.12 –1.07 –2.29 Yes Yes 0.05 No\n3 –3.19 0.94 89.70 –2.76 No No –0.02 0.13 –1.06 –2.27 Yes Yes 0.06 No\n4 –4.11 0.92 87.64 –3.07 No No 0.09 0 –0.74 –1.85 Yes Yes 0.10 No\n5 –6.39 1.06 94.85 –2.49 No No 0.25 0 –0.03 –1.30 Yes Yes 0.22 No\n6 –5.42 1.43 90.49 –2.73 No No 0.05 0 –0.33 –1.29 Yes Yes 0.23 No\n7 –4.54 1.04 91.97 –2.73 No No –0.37 0 0.28 –2.20 Yes Yes 0.13 No\n8 –5.09 1.66 90.44 –2.29 No No 0.27 0 0.16 –1.47 No Yes 0.14 No\n9 –7.03 1.13 93.34 –2.51 No No 0.37 0 0.46 –1.26 Yes Yes 0.26 No\n10 –4.89 0.94 91.50 –2.74 No No –0.04 0 –0.24 –1.93 Yes Yes 0.11 No\n11 –5.93 1.28 89.16 –2.59 No No 0.36 0 0.66 –1.40 No Yes 0.13 No\n12 –6.99 1.02 91.30 –2.75 No No 0.66 0 –0.32 –1.85 Yes Yes 1.04 No\n13 –5.42 1.27 92.76 –2.80 Yes Yes 0.54 0 –0.02 –1.58 Yes Yes 0.26 No\n14 –4.20 1.12 90.31 –2.92 No No –0.04 0.01 –0.31 –1.33 No Yes 0.08 No\n15 –3.76 0.97 88.86 –2.79 No No 1.90 0.16 –0.20 –1.26 No No 1.01 Yes\n16 –6.92 0.90 94.67 –2.73 No No –0.59 0.07 –0.72 –2.62 No Yes 0.41 No\nDMC –3.95 0.99 92.03 –2.74 No No –0.06 0.12 –0.23 –2.66 Yes Yes 0.32 No\nFAC –4.02 1.41 83.68 –2.76 Yes Yes –0.58 0.24 –0.91 –3.26 Yes Yes 0.55 No\nIBC –4.36 0.91 91.72 –2.73 No No –0.88 0.18 –0.53 –2.77 Yes Yes 0.62 No\nIVC –3.95 0.96 89.31 –2.73 No No –0.60 0.24 –1.37 –3.02 Yes Yes 0.16 No\nSYC –3.89 1.01 89.15 –2.73 No No 0.28 0.17 –1.47 –3.14 Yes Yes 0.23 No\n[a]  Abbreviations: WS—Water solubility (log mol/L), CP—Caco2 permeability (log Papp in 10-6 cm/s), IA—Human intestinal absorption (% Absorbed), SP—Skin permeability (log Kp),PI-1—P-glycoprotein I inhibitor, PI-2—P-glycoprotein II inhibitor, VD—Human volume ofdistribution (log L/kg), FU—Fraction unbound (human) (Fu), BBB—BBB permeability (logBB), CNS—CNS permeability (log PS), CI-1—CYP3A4 inhibitor, CI-2—CYP2C9 inhibitor,TC—Total clearance (log mL/min/kg), RS—Renal OCT2 (organic cation transporter 2) substrate. BHBC: 3-5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, MNC: 4-methoxy-1-naphthaldehyde curcumin, BDMC: Bis-demethoxy curcumin, DMC: Demethoxy curcumin, FAC: Ferulic-acid curcumin, IBC: Ibuprofen curcumin, IVC: Isovanillin curcumin, SYC: Syringaldehyde curcumin."}

{"project":"LitCovid-PubTator","denotations":[{"id":"649","span":{"begin":40,"end":48},"obj":"Chemical"},{"id":"653","span":{"begin":187,"end":191},"obj":"Chemical"},{"id":"654","span":{"begin":361,"end":365},"obj":"Chemical"},{"id":"655","span":{"begin":97,"end":132},"obj":"Disease"},{"id":"683","span":{"begin":2363,"end":2377},"obj":"Gene"},{"id":"684","span":{"begin":2568,"end":2574},"obj":"Gene"},{"id":"685","span":{"begin":2591,"end":2597},"obj":"Gene"},{"id":"686","span":{"begin":2653,"end":2657},"obj":"Gene"},{"id":"687","span":{"begin":2659,"end":2687},"obj":"Gene"},{"id":"688","span":{"begin":2286,"end":2291},"obj":"Species"},{"id":"689","span":{"begin":2391,"end":2395},"obj":"Species"},{"id":"690","span":{"begin":2428,"end":2433},"obj":"Species"},{"id":"691","span":{"begin":2489,"end":2494},"obj":"Species"},{"id":"692","span":{"begin":2396,"end":2410},"obj":"Gene"},{"id":"693","span":{"begin":2206,"end":2211},"obj":"Chemical"},{"id":"694","span":{"begin":2700,"end":2704},"obj":"Chemical"},{"id":"695","span":{"begin":2706,"end":2745},"obj":"Chemical"},{"id":"696","span":{"begin":2746,"end":2754},"obj":"Chemical"},{"id":"697","span":{"begin":2756,"end":2759},"obj":"Chemical"},{"id":"698","span":{"begin":2761,"end":2787},"obj":"Chemical"},{"id":"699","span":{"begin":2788,"end":2796},"obj":"Chemical"},{"id":"700","span":{"begin":2798,"end":2802},"obj":"Chemical"},{"id":"701","span":{"begin":2804,"end":2826},"obj":"Chemical"},{"id":"702","span":{"begin":2833,"end":2851},"obj":"Chemical"},{"id":"703","span":{"begin":2858,"end":2870},"obj":"Chemical"},{"id":"704","span":{"begin":2871,"end":2879},"obj":"Chemical"},{"id":"705","span":{"begin":2881,"end":2884},"obj":"Chemical"},{"id":"706","span":{"begin":2886,"end":2904},"obj":"Chemical"},{"id":"707","span":{"begin":2911,"end":2931},"obj":"Chemical"},{"id":"708","span":{"begin":2938,"end":2952},"obj":"Chemical"},{"id":"709","span":{"begin":2953,"end":2961},"obj":"Chemical"}],"attributes":[{"id":"A649","pred":"tao:has_database_id","subj":"649","obj":"MESH:D003474"},{"id":"A655","pred":"tao:has_database_id","subj":"655","obj":"MESH:D018980"},{"id":"A683","pred":"tao:has_database_id","subj":"683","obj":"Gene:5243"},{"id":"A684","pred":"tao:has_database_id","subj":"684","obj":"Gene:1576"},{"id":"A685","pred":"tao:has_database_id","subj":"685","obj":"Gene:1559"},{"id":"A686","pred":"tao:has_database_id","subj":"686","obj":"Gene:6582"},{"id":"A687","pred":"tao:has_database_id","subj":"687","obj":"Gene:6582"},{"id":"A688","pred":"tao:has_database_id","subj":"688","obj":"Tax:9606"},{"id":"A689","pred":"tao:has_database_id","subj":"689","obj":"Tax:1214577"},{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"Tax:9606"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"Tax:9606"},{"id":"A692","pred":"tao:has_database_id","subj":"692","obj":"Gene:5243"},{"id":"A693","pred":"tao:has_database_id","subj":"693","obj":"MESH:D014867"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"MESH:C513957"},{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"MESH:D003474"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"MESH:D003474"},{"id":"A701","pred":"tao:has_database_id","subj":"701","obj":"MESH:C034786"},{"id":"A702","pred":"tao:has_database_id","subj":"702","obj":"MESH:C050229"},{"id":"A703","pred":"tao:has_database_id","subj":"703","obj":"MESH:C004999"},{"id":"A704","pred":"tao:has_database_id","subj":"704","obj":"MESH:D003474"},{"id":"A705","pred":"tao:has_database_id","subj":"705","obj":"MESH:D002015"},{"id":"A708","pred":"tao:has_database_id","subj":"708","obj":"MESH:C069665"},{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"MESH:D003474"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 5. In-silico ADME prediction for curcumin derivatives[a].\nComp Absorption Distribution Metabolism Excretion\n  WS CP IA SP PI-1 PI-2 VD FU BBB CNS CI-1 CI-2 TC RS\nBHBC –2.91 0.67 88.62 –2.73 Yes Yes –0.39 0.31 –0.67 –0.85 No Yes 0.15 No\nMNC –3.64 0.43 100 –2.73 Yes Yes –1.45 0.33 –0.39 –2.73 Yes Yes 0.26 No\nBDMC –4.43 1.01 95.92 –2.99 No No –0.22 0.08 –0.72 –2.11 Yes Yes 0.12 No\n1 –4.66 1.25 91.80 –2.51 No No 0.18 0.06 0.01 –1.45 Yes Yes 0.10 No\n2 –3.23 0.93 89.16 –2.76 No No –0.07 0.12 –1.07 –2.29 Yes Yes 0.05 No\n3 –3.19 0.94 89.70 –2.76 No No –0.02 0.13 –1.06 –2.27 Yes Yes 0.06 No\n4 –4.11 0.92 87.64 –3.07 No No 0.09 0 –0.74 –1.85 Yes Yes 0.10 No\n5 –6.39 1.06 94.85 –2.49 No No 0.25 0 –0.03 –1.30 Yes Yes 0.22 No\n6 –5.42 1.43 90.49 –2.73 No No 0.05 0 –0.33 –1.29 Yes Yes 0.23 No\n7 –4.54 1.04 91.97 –2.73 No No –0.37 0 0.28 –2.20 Yes Yes 0.13 No\n8 –5.09 1.66 90.44 –2.29 No No 0.27 0 0.16 –1.47 No Yes 0.14 No\n9 –7.03 1.13 93.34 –2.51 No No 0.37 0 0.46 –1.26 Yes Yes 0.26 No\n10 –4.89 0.94 91.50 –2.74 No No –0.04 0 –0.24 –1.93 Yes Yes 0.11 No\n11 –5.93 1.28 89.16 –2.59 No No 0.36 0 0.66 –1.40 No Yes 0.13 No\n12 –6.99 1.02 91.30 –2.75 No No 0.66 0 –0.32 –1.85 Yes Yes 1.04 No\n13 –5.42 1.27 92.76 –2.80 Yes Yes 0.54 0 –0.02 –1.58 Yes Yes 0.26 No\n14 –4.20 1.12 90.31 –2.92 No No –0.04 0.01 –0.31 –1.33 No Yes 0.08 No\n15 –3.76 0.97 88.86 –2.79 No No 1.90 0.16 –0.20 –1.26 No No 1.01 Yes\n16 –6.92 0.90 94.67 –2.73 No No –0.59 0.07 –0.72 –2.62 No Yes 0.41 No\nDMC –3.95 0.99 92.03 –2.74 No No –0.06 0.12 –0.23 –2.66 Yes Yes 0.32 No\nFAC –4.02 1.41 83.68 –2.76 Yes Yes –0.58 0.24 –0.91 –3.26 Yes Yes 0.55 No\nIBC –4.36 0.91 91.72 –2.73 No No –0.88 0.18 –0.53 –2.77 Yes Yes 0.62 No\nIVC –3.95 0.96 89.31 –2.73 No No –0.60 0.24 –1.37 –3.02 Yes Yes 0.16 No\nSYC –3.89 1.01 89.15 –2.73 No No 0.28 0.17 –1.47 –3.14 Yes Yes 0.23 No\n[a]  Abbreviations: WS—Water solubility (log mol/L), CP—Caco2 permeability (log Papp in 10-6 cm/s), IA—Human intestinal absorption (% Absorbed), SP—Skin permeability (log Kp),PI-1—P-glycoprotein I inhibitor, PI-2—P-glycoprotein II inhibitor, VD—Human volume ofdistribution (log L/kg), FU—Fraction unbound (human) (Fu), BBB—BBB permeability (logBB), CNS—CNS permeability (log PS), CI-1—CYP3A4 inhibitor, CI-2—CYP2C9 inhibitor,TC—Total clearance (log mL/min/kg), RS—Renal OCT2 (organic cation transporter 2) substrate. BHBC: 3-5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, MNC: 4-methoxy-1-naphthaldehyde curcumin, BDMC: Bis-demethoxy curcumin, DMC: Demethoxy curcumin, FAC: Ferulic-acid curcumin, IBC: Ibuprofen curcumin, IVC: Isovanillin curcumin, SYC: Syringaldehyde curcumin."}