> top > docs > PMC:7784829 > spans > 23424-26386 > annotations

PMC:7784829 / 23424-26386 JSONTXT

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LitCovid-sentences

Id Subject Object Predicate Lexical cue
T253 0-8 Sentence denotes Table 5.
T254 10-64 Sentence denotes In-silico ADME prediction for curcumin derivatives[a].
T255 65-118 Sentence denotes Comp Absorption Distribution Metabolism Excretion
T256 119-186 Sentence denotes   WS CP IA SP PI-1 PI-2 VD FU BBB CNS CI-1 CI-2 TC RS
T257 187-274 Sentence denotes BHBC –2.91 0.67 88.62 –2.73 Yes Yes –0.39 0.31 –0.67 –0.85 No Yes 0.15 No
T258 275-360 Sentence denotes MNC –3.64 0.43 100 –2.73 Yes Yes –1.45 0.33 –0.39 –2.73 Yes Yes 0.26 No
T259 361-447 Sentence denotes BDMC –4.43 1.01 95.92 –2.99 No No –0.22 0.08 –0.72 –2.11 Yes Yes 0.12 No
T260 448-529 Sentence denotes 1 –4.66 1.25 91.80 –2.51 No No 0.18 0.06 0.01 –1.45 Yes Yes 0.10 No
T261 530-613 Sentence denotes 2 –3.23 0.93 89.16 –2.76 No No –0.07 0.12 –1.07 –2.29 Yes Yes 0.05 No
T262 614-697 Sentence denotes 3 –3.19 0.94 89.70 –2.76 No No –0.02 0.13 –1.06 –2.27 Yes Yes 0.06 No
T263 698-777 Sentence denotes 4 –4.11 0.92 87.64 –3.07 No No 0.09 0 –0.74 –1.85 Yes Yes 0.10 No
T264 778-857 Sentence denotes 5 –6.39 1.06 94.85 –2.49 No No 0.25 0 –0.03 –1.30 Yes Yes 0.22 No
T265 858-937 Sentence denotes 6 –5.42 1.43 90.49 –2.73 No No 0.05 0 –0.33 –1.29 Yes Yes 0.23 No
T266 938-1017 Sentence denotes 7 –4.54 1.04 91.97 –2.73 No No –0.37 0 0.28 –2.20 Yes Yes 0.13 No
T267 1018-1095 Sentence denotes 8 –5.09 1.66 90.44 –2.29 No No 0.27 0 0.16 –1.47 No Yes 0.14 No
T268 1096-1174 Sentence denotes 9 –7.03 1.13 93.34 –2.51 No No 0.37 0 0.46 –1.26 Yes Yes 0.26 No
T269 1175-1256 Sentence denotes 10 –4.89 0.94 91.50 –2.74 No No –0.04 0 –0.24 –1.93 Yes Yes 0.11 No
T270 1257-1335 Sentence denotes 11 –5.93 1.28 89.16 –2.59 No No 0.36 0 0.66 –1.40 No Yes 0.13 No
T271 1336-1416 Sentence denotes 12 –6.99 1.02 91.30 –2.75 No No 0.66 0 –0.32 –1.85 Yes Yes 1.04 No
T272 1417-1499 Sentence denotes 13 –5.42 1.27 92.76 –2.80 Yes Yes 0.54 0 –0.02 –1.58 Yes Yes 0.26 No
T273 1500-1583 Sentence denotes 14 –4.20 1.12 90.31 –2.92 No No –0.04 0.01 –0.31 –1.33 No Yes 0.08 No
T274 1584-1666 Sentence denotes 15 –3.76 0.97 88.86 –2.79 No No 1.90 0.16 –0.20 –1.26 No No 1.01 Yes
T275 1667-1750 Sentence denotes 16 –6.92 0.90 94.67 –2.73 No No –0.59 0.07 –0.72 –2.62 No Yes 0.41 No
T276 1751-1836 Sentence denotes DMC –3.95 0.99 92.03 –2.74 No No –0.06 0.12 –0.23 –2.66 Yes Yes 0.32 No
T277 1837-1924 Sentence denotes FAC –4.02 1.41 83.68 –2.76 Yes Yes –0.58 0.24 –0.91 –3.26 Yes Yes 0.55 No
T278 1925-2010 Sentence denotes IBC –4.36 0.91 91.72 –2.73 No No –0.88 0.18 –0.53 –2.77 Yes Yes 0.62 No
T279 2011-2096 Sentence denotes IVC –3.95 0.96 89.31 –2.73 No No –0.60 0.24 –1.37 –3.02 Yes Yes 0.16 No
T280 2097-2181 Sentence denotes SYC –3.89 1.01 89.15 –2.73 No No 0.28 0.17 –1.47 –3.14 Yes Yes 0.23 No
T281 2182-2699 Sentence denotes [a]  Abbreviations: WS—Water solubility (log mol/L), CP—Caco2 permeability (log Papp in 10-6 cm/s), IA—Human intestinal absorption (% Absorbed), SP—Skin permeability (log Kp),PI-1—P-glycoprotein I inhibitor, PI-2—P-glycoprotein II inhibitor, VD—Human volume ofdistribution (log L/kg), FU—Fraction unbound (human) (Fu), BBB—BBB permeability (logBB), CNS—CNS permeability (log PS), CI-1—CYP3A4 inhibitor, CI-2—CYP2C9 inhibitor,TC—Total clearance (log mL/min/kg), RS—Renal OCT2 (organic cation transporter 2) substrate.
T282 2700-2705 Sentence denotes BHBC:
T283 2706-2760 Sentence denotes 3-5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, MNC:
T284 2761-2803 Sentence denotes 4-methoxy-1-naphthaldehyde curcumin, BDMC:
T285 2804-2832 Sentence denotes Bis-demethoxy curcumin, DMC:
T286 2833-2857 Sentence denotes Demethoxy curcumin, FAC:
T287 2858-2885 Sentence denotes Ferulic-acid curcumin, IBC:
T288 2886-2910 Sentence denotes Ibuprofen curcumin, IVC:
T289 2911-2937 Sentence denotes Isovanillin curcumin, SYC:
T290 2938-2962 Sentence denotes Syringaldehyde curcumin.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
649 40-48 Chemical denotes curcumin MESH:D003474
653 187-191 Chemical denotes BHBC
654 361-365 Chemical denotes BDMC
655 97-132 Disease denotes Metabolism Excretion   WS CP IA MESH:D018980
683 2363-2377 Gene denotes P-glycoprotein Gene:5243
684 2568-2574 Gene denotes CYP3A4 Gene:1576
685 2591-2597 Gene denotes CYP2C9 Gene:1559
686 2653-2657 Gene denotes OCT2 Gene:6582
687 2659-2687 Gene denotes organic cation transporter 2 Gene:6582
688 2286-2291 Species denotes Human Tax:9606
689 2391-2395 Species denotes PI-2 Tax:1214577
690 2428-2433 Species denotes Human Tax:9606
691 2489-2494 Species denotes human Tax:9606
692 2396-2410 Gene denotes P-glycoprotein Gene:5243
693 2206-2211 Chemical denotes Water MESH:D014867
694 2700-2704 Chemical denotes BHBC
695 2706-2745 Chemical denotes 3-5-di-tert-butyl-4-hydroxybenzaldehyde MESH:C513957
696 2746-2754 Chemical denotes curcumin MESH:D003474
697 2756-2759 Chemical denotes MNC
698 2761-2787 Chemical denotes 4-methoxy-1-naphthaldehyde
699 2788-2796 Chemical denotes curcumin MESH:D003474
700 2798-2802 Chemical denotes BDMC
701 2804-2826 Chemical denotes Bis-demethoxy curcumin MESH:C034786
702 2833-2851 Chemical denotes Demethoxy curcumin MESH:C050229
703 2858-2870 Chemical denotes Ferulic-acid MESH:C004999
704 2871-2879 Chemical denotes curcumin MESH:D003474
705 2881-2884 Chemical denotes IBC MESH:D002015
706 2886-2904 Chemical denotes Ibuprofen curcumin
707 2911-2931 Chemical denotes Isovanillin curcumin
708 2938-2952 Chemical denotes Syringaldehyde MESH:C069665
709 2953-2961 Chemical denotes curcumin MESH:D003474