PMC:7784829 / 21808-23423
Annnotations
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T243","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T244","span":{"begin":156,"end":190},"obj":"Sentence"},{"id":"T245","span":{"begin":191,"end":493},"obj":"Sentence"},{"id":"T246","span":{"begin":494,"end":617},"obj":"Sentence"},{"id":"T247","span":{"begin":618,"end":706},"obj":"Sentence"},{"id":"T248","span":{"begin":707,"end":941},"obj":"Sentence"},{"id":"T249","span":{"begin":942,"end":1079},"obj":"Sentence"},{"id":"T250","span":{"begin":1080,"end":1253},"obj":"Sentence"},{"id":"T251","span":{"begin":1254,"end":1406},"obj":"Sentence"},{"id":"T252","span":{"begin":1407,"end":1615},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Additionally, a variety of key ADMET (Absorption, Distribution, Metabolism and Excretion) properties have also been calculated with the aid of pkCSMserver. The results are listed in Table 5. All curcumin derivatives showed moderate to high water solubility ranging from −2.91 log mol/L (BHBC) to −6.99 log mol/L (compound-12), in addition to high Caco-2 permeability (permeation \u003e 0.90) except compound BHBC and MNC (permeation = 0.67 and 0.43 respectively) which showed moderate permeability. Intestinal absorption (IA) has been found to be greater than 85% indicating good permeation across the intestinal membrane. Further, all curcumin compounds showed good permeation through skin (permeation \u003e −2.5). Additionally, all curcumin compounds showed no inhibition towards P-glycoprotein I and P-glycoprotein II, except compounds BHBC, MNC, compound-13 and Ferrulic acid curcumin (FAC) which demonstrated inhibition towards P-glycoprotein I. Furthermore, all curcumin compounds showed poor BBB permeability and moderate CNS permeability except Isovanillin curcumin (IVC) and SYC. All showed inhibition towards the metabolizing enzyme CYP3A4 except BHBC, compounds-8, -11, -14, -15 and -16, while except compound-15, all showed inhibition towards CYP2C9. All curcumin derivatives were found to show the total clearance in the range 0.10 log mL/min/kg (compound-1 and -4) to 1.01 log mL/min/kg (compound-15). Further, all curcumin derivatives except compound 15 were found to act as OCT2 substrate, thus indicating that these compounds will not have any adverse interactions and no negative effect on renal clearance."}
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"625","span":{"begin":773,"end":787},"obj":"Gene"},{"id":"626","span":{"begin":794,"end":808},"obj":"Gene"},{"id":"627","span":{"begin":1134,"end":1140},"obj":"Gene"},{"id":"628","span":{"begin":1154,"end":1188},"obj":"Gene"},{"id":"629","span":{"begin":1246,"end":1252},"obj":"Gene"},{"id":"630","span":{"begin":1350,"end":1368},"obj":"Gene"},{"id":"631","span":{"begin":1481,"end":1485},"obj":"Gene"},{"id":"632","span":{"begin":31,"end":36},"obj":"Chemical"},{"id":"633","span":{"begin":195,"end":203},"obj":"Chemical"},{"id":"634","span":{"begin":240,"end":245},"obj":"Chemical"},{"id":"635","span":{"begin":287,"end":291},"obj":"Chemical"},{"id":"636","span":{"begin":347,"end":353},"obj":"Chemical"},{"id":"637","span":{"begin":403,"end":407},"obj":"Chemical"},{"id":"638","span":{"begin":631,"end":639},"obj":"Chemical"},{"id":"639","span":{"begin":725,"end":733},"obj":"Chemical"},{"id":"640","span":{"begin":830,"end":834},"obj":"Chemical"},{"id":"641","span":{"begin":857,"end":879},"obj":"Chemical"},{"id":"642","span":{"begin":959,"end":967},"obj":"Chemical"},{"id":"643","span":{"begin":1044,"end":1064},"obj":"Chemical"},{"id":"644","span":{"begin":1066,"end":1069},"obj":"Chemical"},{"id":"645","span":{"begin":1148,"end":1152},"obj":"Chemical"},{"id":"646","span":{"begin":1258,"end":1266},"obj":"Chemical"},{"id":"647","span":{"begin":1420,"end":1428},"obj":"Chemical"}],"attributes":[{"id":"A625","pred":"tao:has_database_id","subj":"625","obj":"Gene:5243"},{"id":"A626","pred":"tao:has_database_id","subj":"626","obj":"Gene:5243"},{"id":"A627","pred":"tao:has_database_id","subj":"627","obj":"Gene:1576"},{"id":"A629","pred":"tao:has_database_id","subj":"629","obj":"Gene:1559"},{"id":"A631","pred":"tao:has_database_id","subj":"631","obj":"Gene:6582"},{"id":"A633","pred":"tao:has_database_id","subj":"633","obj":"MESH:D003474"},{"id":"A634","pred":"tao:has_database_id","subj":"634","obj":"MESH:D014867"},{"id":"A638","pred":"tao:has_database_id","subj":"638","obj":"MESH:D003474"},{"id":"A639","pred":"tao:has_database_id","subj":"639","obj":"MESH:D003474"},{"id":"A642","pred":"tao:has_database_id","subj":"642","obj":"MESH:D003474"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"MESH:D003474"},{"id":"A647","pred":"tao:has_database_id","subj":"647","obj":"MESH:D003474"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Additionally, a variety of key ADMET (Absorption, Distribution, Metabolism and Excretion) properties have also been calculated with the aid of pkCSMserver. The results are listed in Table 5. All curcumin derivatives showed moderate to high water solubility ranging from −2.91 log mol/L (BHBC) to −6.99 log mol/L (compound-12), in addition to high Caco-2 permeability (permeation \u003e 0.90) except compound BHBC and MNC (permeation = 0.67 and 0.43 respectively) which showed moderate permeability. Intestinal absorption (IA) has been found to be greater than 85% indicating good permeation across the intestinal membrane. Further, all curcumin compounds showed good permeation through skin (permeation \u003e −2.5). Additionally, all curcumin compounds showed no inhibition towards P-glycoprotein I and P-glycoprotein II, except compounds BHBC, MNC, compound-13 and Ferrulic acid curcumin (FAC) which demonstrated inhibition towards P-glycoprotein I. Furthermore, all curcumin compounds showed poor BBB permeability and moderate CNS permeability except Isovanillin curcumin (IVC) and SYC. All showed inhibition towards the metabolizing enzyme CYP3A4 except BHBC, compounds-8, -11, -14, -15 and -16, while except compound-15, all showed inhibition towards CYP2C9. All curcumin derivatives were found to show the total clearance in the range 0.10 log mL/min/kg (compound-1 and -4) to 1.01 log mL/min/kg (compound-15). Further, all curcumin derivatives except compound 15 were found to act as OCT2 substrate, thus indicating that these compounds will not have any adverse interactions and no negative effect on renal clearance."}