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PMC:7784829 / 21808-23423 JSONTXT

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LitCovid-sentences

Id Subject Object Predicate Lexical cue
T243 0-155 Sentence denotes Additionally, a variety of key ADMET (Absorption, Distribution, Metabolism and Excretion) properties have also been calculated with the aid of pkCSMserver.
T244 156-190 Sentence denotes The results are listed in Table 5.
T245 191-493 Sentence denotes All curcumin derivatives showed moderate to high water solubility ranging from −2.91 log mol/L (BHBC) to −6.99 log mol/L (compound-12), in addition to high Caco-2 permeability (permeation > 0.90) except compound BHBC and MNC (permeation = 0.67 and 0.43 respectively) which showed moderate permeability.
T246 494-617 Sentence denotes Intestinal absorption (IA) has been found to be greater than 85% indicating good permeation across the intestinal membrane.
T247 618-706 Sentence denotes Further, all curcumin compounds showed good permeation through skin (permeation > −2.5).
T248 707-941 Sentence denotes Additionally, all curcumin compounds showed no inhibition towards P-glycoprotein I and P-glycoprotein II, except compounds BHBC, MNC, compound-13 and Ferrulic acid curcumin (FAC) which demonstrated inhibition towards P-glycoprotein I.
T249 942-1079 Sentence denotes Furthermore, all curcumin compounds showed poor BBB permeability and moderate CNS permeability except Isovanillin curcumin (IVC) and SYC.
T250 1080-1253 Sentence denotes All showed inhibition towards the metabolizing enzyme CYP3A4 except BHBC, compounds-8, -11, -14, -15 and -16, while except compound-15, all showed inhibition towards CYP2C9.
T251 1254-1406 Sentence denotes All curcumin derivatives were found to show the total clearance in the range 0.10 log mL/min/kg (compound-1 and -4) to 1.01 log mL/min/kg (compound-15).
T252 1407-1615 Sentence denotes Further, all curcumin derivatives except compound 15 were found to act as OCT2 substrate, thus indicating that these compounds will not have any adverse interactions and no negative effect on renal clearance.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
625 773-787 Gene denotes P-glycoprotein Gene:5243
626 794-808 Gene denotes P-glycoprotein Gene:5243
627 1134-1140 Gene denotes CYP3A4 Gene:1576
628 1154-1188 Gene denotes compounds-8, -11, -14, -15 and -16
629 1246-1252 Gene denotes CYP2C9 Gene:1559
630 1350-1368 Gene denotes (compound-1 and -4
631 1481-1485 Gene denotes OCT2 Gene:6582
632 31-36 Chemical denotes ADMET
633 195-203 Chemical denotes curcumin MESH:D003474
634 240-245 Chemical denotes water MESH:D014867
635 287-291 Chemical denotes BHBC
636 347-353 Chemical denotes Caco-2
637 403-407 Chemical denotes BHBC
638 631-639 Chemical denotes curcumin MESH:D003474
639 725-733 Chemical denotes curcumin MESH:D003474
640 830-834 Chemical denotes BHBC
641 857-879 Chemical denotes Ferrulic acid curcumin
642 959-967 Chemical denotes curcumin MESH:D003474
643 1044-1064 Chemical denotes Isovanillin curcumin
644 1066-1069 Chemical denotes IVC
645 1148-1152 Chemical denotes BHBC
646 1258-1266 Chemical denotes curcumin MESH:D003474
647 1420-1428 Chemical denotes curcumin MESH:D003474