PMC:7784829 / 18296-18704 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784829","sourcedb":"PMC","sourceid":"7784829","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784829","text":"The curcumin derivative with the best binding affinity was Bis-demethoxycurcumin for both 6CRV (ΔG = −10.98 kcal/mol) and 6M0J (ΔG = −10.01 kcal/mol). The native compound, curcumin, demonstrated a binding energy of −9.81 kcal/mol for 6M0J and −10.1 kcal/mol for 6CRV. Binding mode of Bis-demethoxycurcumin with SARS-CoV Spike protein and SARS-CoV-2 Spike protein RBD is shown in Figure 2 and 3, respectively.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T194","span":{"begin":0,"end":150},"obj":"Sentence"},{"id":"T195","span":{"begin":151,"end":267},"obj":"Sentence"},{"id":"T196","span":{"begin":268,"end":408},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T194","pred":"source","obj":"LitCovid-sentences"},{"subj":"T195","pred":"source","obj":"LitCovid-sentences"},{"subj":"T196","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"496","span":{"begin":320,"end":325},"obj":"Gene"},{"id":"497","span":{"begin":349,"end":354},"obj":"Gene"},{"id":"498","span":{"begin":311,"end":319},"obj":"Species"},{"id":"499","span":{"begin":338,"end":348},"obj":"Species"},{"id":"500","span":{"begin":4,"end":12},"obj":"Chemical"},{"id":"501","span":{"begin":59,"end":80},"obj":"Chemical"},{"id":"502","span":{"begin":172,"end":180},"obj":"Chemical"},{"id":"503","span":{"begin":284,"end":305},"obj":"Chemical"}],"attributes":[{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"Gene:43740568"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"Gene:43740568"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"Tax:694009"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"Tax:2697049"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"MESH:D003474"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"MESH:C034786"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"MESH:D003474"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"MESH:C034786"},{"subj":"496","pred":"source","obj":"LitCovid-PubTator"},{"subj":"497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"501","pred":"source","obj":"LitCovid-PubTator"},{"subj":"502","pred":"source","obj":"LitCovid-PubTator"},{"subj":"503","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#ec93e8","default":true},{"id":"LitCovid-PubTator","color":"#93ecd6"}]}]}}