PMC:7784829 / 10414-12422 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784829","sourcedb":"PMC","sourceid":"7784829","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784829","text":"Results\n\nSequence alignment of the SARS-CoV-2 and SARS-CoV spike protein sequences\nPrior to performing the docking studies the multiple sequence alignment was carried out for the spike proteins of the novel corona virus, SARS-CoV-2 and the 2002 SARS-CoV (Supplementary Figure 1 and Table 1). These results show that there is a very high percentage identity (greater than 99%) among the spike protein of the novel corona virus SARS-CoV-2 strains. There was around 74% identity of the SARS-CoV-2 spike proteins with the 2002 SARS-CoV. Therefore, the SARS-CoV-2 spike protein is very much closer to SARS-CoV than to the other corona viruses as shown in other studies (Ahmed et al., 2020).\nFigure 1. The curcumin and its derivatives which displayed high binding affinity for SARS-CoV-2 and SARS-CoV spike proteins.\nTable 1. Percentage identity Matrix of Spike glycoprotein of SARS-CoV-2 and SARS-CoV. Indian 1 and 2 (QHS34546.1 and QIA98583.1), Korea (QHZ00379.1), Brazil (QIG55994.1), USA (QHO60594.1), Wuhan (QHD43416.1), Pakistan (QIQ22760.1), Italy (QIA98554.1), Australia (QHR84449.1) are spike proteins from SARS-CoV-2. SARS-6CRV is the spike protein from the 2002 SARS-CoV spike protein (6CRV).\nViral Strain SARS-CoV Indian1 Korea Indian2 Brazil USA Wuhan Pakistan Italy Australia\nSARS-CoV 100 73.75 73.77 73.69 73.77 73.77 73.77 73.77 73.77 73.77\nIndian1 73.75 100 99.84 99.84 99.92 99.92 99.92 99.92 99.92 99.84\nKorea 73.77 99.84 100 99.84 99.92 99.92 99.92 99.92 99.92 99.84\nIndian2 73.69 99.84 99.84 100 99.92 99.92 99.92 99.92 99.92 99.84\nBrazil 73.77 99.92 99.92 99.92 100 100 100 100 100 99.92\nUSA 73.77 99.92 99.92 99.92 100 100 100 100 100 99.92\nWuhan 73.77 99.92 99.92 99.92 100 100 100 100 100 99.92\nPakistan 73.77 99.92 99.92 99.92 100 100 100 100 100 99.92\nItaly 73.77 99.92 99.92 99.92 100 100 100 100 100 99.92\nAustralia 73.77 99.84 99.84 99.84 99.92 99.92 99.92 99.92 99.92 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