PMC:7784828 / 8548-10076 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784828","sourcedb":"PMC","sourceid":"7784828","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784828","text":"The lack of ample effective and affordable medicines is one of the vexing challenges faced globally. It is imperative to generate novel treatment strategies, however, fair pricing and quick access to medicines remain a massive global challenge. Chronic shortages and rising demands for critical drugs affect patient community with many dying from easily curable diseases [24]. To a large extent, present day drug development and discovery is controlled oftentimes by private entities which are driven by vested economic interests and boundary conditions. This leads to the burden trickling down to patients, their families and carers either through lack of effective medicines or mounting financial costs. Addressing these global issues is the need of the hour and a plausible solution could be devising new tools and technologies, novel methodological approaches, and infrastructural changes to streamline the drug discovery review processes. On the other hand, the desperate need for new effective drugs raises a concern over the efficacy of many of the currently marketed drugs. A study examining efficacy of solid tumors therapies approved by the FDA between 2002 and 2014, found only 30 out of 71 therapies (42%) to have modest clinically meaningful improvements [25]. Sluggish data sharing and irreproducibility of published research remains as another major challenge. A 2016 survey of 1,576 researchers by the journal Nature found that over 70% of researchers have failed to reproduce other scientist’s experiments [26].","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T83","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T84","span":{"begin":101,"end":244},"obj":"Sentence"},{"id":"T85","span":{"begin":245,"end":376},"obj":"Sentence"},{"id":"T86","span":{"begin":377,"end":554},"obj":"Sentence"},{"id":"T87","span":{"begin":555,"end":705},"obj":"Sentence"},{"id":"T88","span":{"begin":706,"end":943},"obj":"Sentence"},{"id":"T89","span":{"begin":944,"end":1081},"obj":"Sentence"},{"id":"T90","span":{"begin":1082,"end":1273},"obj":"Sentence"},{"id":"T91","span":{"begin":1274,"end":1375},"obj":"Sentence"},{"id":"T92","span":{"begin":1376,"end":1528},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T83","pred":"source","obj":"LitCovid-sentences"},{"subj":"T84","pred":"source","obj":"LitCovid-sentences"},{"subj":"T85","pred":"source","obj":"LitCovid-sentences"},{"subj":"T86","pred":"source","obj":"LitCovid-sentences"},{"subj":"T87","pred":"source","obj":"LitCovid-sentences"},{"subj":"T88","pred":"source","obj":"LitCovid-sentences"},{"subj":"T89","pred":"source","obj":"LitCovid-sentences"},{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"},{"subj":"T92","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"125","span":{"begin":308,"end":315},"obj":"Species"},{"id":"126","span":{"begin":598,"end":606},"obj":"Species"},{"id":"127","span":{"begin":1118,"end":1124},"obj":"Disease"}],"attributes":[{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"Tax:9606"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"Tax:9606"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:D009369"},{"subj":"125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"127","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#ecda93","default":true},{"id":"LitCovid-PubTator","color":"#c093ec"}]}]}}