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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784828","sourcedb":"PMC","sourceid":"7784828","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784828","text":"Article highlights\nPatients desperately want effective affordable drugs and they want them quickly.\nDrug development needs massive changes in the currently followed procedures.\nDespite the advancement of technology, there are many unmet needs for the treatment of many diseases including infectious diseases, CNS diseases, Alzheimer’s, rare diseases and cancer.\nDespite the alarming pace of serious diseases, the drug development community has not yet embraced pooling the crowd sources of science to implement new reforms in drug development.\nLack of enough global alliance, secrecy, duplication of efforts, cost, pace and reproducibility elements are among the mitigating factors that need to be addressed.\nThis box summarizes key points contained in the article.\n\nDeclaration of interest\nThe authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.\n\nReviewer disclosures\nPeer reviewers on this manuscript have no relevant financial or other relationships to 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