PMC:7784824 / 2772-3787 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":907,"end":916},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"Considering the extent of the pandemic, its socio-economic impact, and the effect on healthcare systems worldwide, there is a high need to extend the diagnostic capacity. So far, the gold standard for the diagnosis of SARS-CoV-2, implemented at the start of the outbreak, is real-time reverse transcriptase polymerase chain reaction (RT-PCR) [6]. In contrast with a high specificity up to 98.8% [7], RT-PCR suffers from a rather long turnaround time when performed in batch testing (2 to 6 hours). Continuous PCR testing has a faster turnaround time (1 u) but a low capacity. False negative results in both the very early as well as the late phase of the disease due to low virus shedding at these stages of infection are reported [8–10]. Studies have shown discrepant results between RT-PCR and chest computed tomography (CT) findings [11,12]. CT imaging findings in 30 patients with suspicion of COVID-19 pneumonia were shown to have a sensitivity of 97.2% compared to 83.3% of initial nasopharyngeal RT-PCR [13]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"52","span":{"begin":218,"end":228},"obj":"Species"},{"id":"53","span":{"begin":871,"end":879},"obj":"Species"},{"id":"54","span":{"begin":708,"end":717},"obj":"Disease"},{"id":"55","span":{"begin":898,"end":916},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:2697049"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:9606"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"MESH:D007239"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Considering the extent of the pandemic, its socio-economic impact, and the effect on healthcare systems worldwide, there is a high need to extend the diagnostic capacity. So far, the gold standard for the diagnosis of SARS-CoV-2, implemented at the start of the outbreak, is real-time reverse transcriptase polymerase chain reaction (RT-PCR) [6]. In contrast with a high specificity up to 98.8% [7], RT-PCR suffers from a rather long turnaround time when performed in batch testing (2 to 6 hours). Continuous PCR testing has a faster turnaround time (1 u) but a low capacity. False negative results in both the very early as well as the late phase of the disease due to low virus shedding at these stages of infection are reported [8–10]. Studies have shown discrepant results between RT-PCR and chest computed tomography (CT) findings [11,12]. CT imaging findings in 30 patients with suspicion of COVID-19 pneumonia were shown to have a sensitivity of 97.2% compared to 83.3% of initial nasopharyngeal RT-PCR [13]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T34","span":{"begin":0,"end":170},"obj":"Sentence"},{"id":"T35","span":{"begin":171,"end":346},"obj":"Sentence"},{"id":"T36","span":{"begin":347,"end":497},"obj":"Sentence"},{"id":"T37","span":{"begin":498,"end":575},"obj":"Sentence"},{"id":"T38","span":{"begin":576,"end":738},"obj":"Sentence"},{"id":"T39","span":{"begin":739,"end":844},"obj":"Sentence"},{"id":"T40","span":{"begin":845,"end":1015},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Considering the extent of the pandemic, its socio-economic impact, and the effect on healthcare systems worldwide, there is a high need to extend the diagnostic capacity. So far, the gold standard for the diagnosis of SARS-CoV-2, implemented at the start of the outbreak, is real-time reverse transcriptase polymerase chain reaction (RT-PCR) [6]. In contrast with a high specificity up to 98.8% [7], RT-PCR suffers from a rather long turnaround time when performed in batch testing (2 to 6 hours). Continuous PCR testing has a faster turnaround time (1 u) but a low capacity. False negative results in both the very early as well as the late phase of the disease due to low virus shedding at these stages of infection are reported [8–10]. Studies have shown discrepant results between RT-PCR and chest computed tomography (CT) findings [11,12]. CT imaging findings in 30 patients with suspicion of COVID-19 pneumonia were shown to have a sensitivity of 97.2% compared to 83.3% of initial nasopharyngeal RT-PCR [13]."}