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PMC:7784786 / 7257-10221 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
303 1066-1069 Gene denotes AST Gene:26503
304 1097-1115 Gene denotes C-reactive protein Gene:1401
305 1238-1246 Gene denotes IFN α-2b Gene:3440
306 2202-2206 Gene denotes IL-6 Gene:3569
307 2317-2321 Gene denotes IL-6 Gene:3569
308 2474-2478 Gene denotes IL-6 Gene:3569
309 2522-2526 Gene denotes IL-6 Gene:3569
310 2528-2532 Gene denotes IL-1 Gene:3553
311 2613-2616 Gene denotes AST Gene:26503
312 969-976 Species denotes Patient Tax:9606
313 1640-1647 Species denotes patient Tax:9606
314 1914-1921 Species denotes patient Tax:9606
315 2115-2122 Species denotes patient Tax:9606
316 2768-2775 Species denotes patient Tax:9606
317 661-667 Chemical denotes oxygen MESH:D010100
318 1204-1223 Chemical denotes lopinavir–ritonavir MESH:C558899
319 1225-1236 Chemical denotes chloroquine MESH:D002738
320 1248-1257 Chemical denotes meropenem MESH:D000077731
321 1262-1271 Chemical denotes linezolid MESH:D000069349
322 1328-1338 Chemical denotes itolizumab MESH:C000597346
323 1470-1473 Chemical denotes PO2 MESH:C093415
324 1474-1478 Chemical denotes FiO2
325 1522-1525 Chemical denotes PO2 MESH:C093415
326 1526-1530 Chemical denotes FiO2
327 1556-1559 Chemical denotes PO2 MESH:C093415
328 2147-2157 Chemical denotes itolizumab MESH:C000597346
329 2236-2246 Chemical denotes itolizumab MESH:C000597346
330 2859-2873 Chemical denotes norepinephrine MESH:D009638
331 65-85 Disease denotes ischemic cardiopathy MESH:C536187
332 97-116 Disease denotes atrial fibrillation MESH:D001281
333 118-130 Disease denotes hypertension MESH:D006973
334 135-149 Disease denotes hypothyroidism MESH:D007037
335 180-190 Disease denotes alcoholism MESH:D000437
336 269-289 Disease denotes respiratory diseases MESH:D012140
337 342-361 Disease denotes shortness of breath MESH:D004417
338 363-368 Disease denotes fever MESH:D005334
339 370-378 Disease denotes asthenia MESH:D001247
340 383-392 Disease denotes dry cough MESH:D003371
341 469-477 Disease denotes COVID-19 MESH:C000657245
342 529-548 Disease denotes respiratory failure MESH:D012131
343 566-577 Disease denotes tachycardia MESH:D013610
344 579-587 Disease denotes polypnea
345 840-859 Disease denotes atrial fibrillation MESH:D001281
346 932-941 Disease denotes hypoxemia MESH:D000860
347 946-967 Disease denotes respiratory alkalosis MESH:D000472
348 986-998 Disease denotes leukocytosis MESH:D007964
349 1713-1737 Disease denotes alveolar hypoventilation MESH:C536281
350 1767-1779 Disease denotes pneumothorax MESH:D011030
351 1814-1826 Disease denotes pneumothorax MESH:D011030
352 2788-2810 Disease denotes myocardial dysfunction MESH:D009202
353 2815-2820 Disease denotes shock MESH:D012769
354 2897-2901 Disease denotes died MESH:D003643
355 2925-2963 Disease denotes cardiovascular and respiratory failure MESH:D012131

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T19 87-116 Phenotype denotes permanent atrial fibrillation http://purl.obolibrary.org/obo/HP_0004754
T20 118-130 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T21 135-149 Phenotype denotes hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T22 180-190 Phenotype denotes alcoholism http://purl.obolibrary.org/obo/HP_0030955
T23 342-361 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T24 363-368 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T25 370-378 Phenotype denotes asthenia http://purl.obolibrary.org/obo/HP_0025406
T26 383-392 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T27 529-548 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T28 566-577 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649
T29 579-587 Phenotype denotes polypnea http://purl.obolibrary.org/obo/HP_0002789
T30 640-659 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T31 705-715 Phenotype denotes drowsiness http://purl.obolibrary.org/obo/HP_0002329
T32 840-859 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T33 932-941 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T34 946-967 Phenotype denotes respiratory alkalosis http://purl.obolibrary.org/obo/HP_0001950
T35 986-998 Phenotype denotes leukocytosis http://purl.obolibrary.org/obo/HP_0001974
T36 1389-1410 Phenotype denotes pulmonary infiltrates http://purl.obolibrary.org/obo/HP_0002113
T37 1713-1737 Phenotype denotes alveolar hypoventilation http://purl.obolibrary.org/obo/HP_0002791
T38 1742-1753 Phenotype denotes atelectasis http://purl.obolibrary.org/obo/HP_0100750
T39 1767-1779 Phenotype denotes pneumothorax http://purl.obolibrary.org/obo/HP_0002107
T40 1814-1826 Phenotype denotes pneumothorax http://purl.obolibrary.org/obo/HP_0002107
T41 2815-2820 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T42 2944-2963 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T66 0-10 Sentence denotes Patient 2:
T67 11-150 Sentence denotes An 89-year old man with a personal history of chronic ischemic cardiopathy, permanent atrial fibrillation, hypertension and hypothyroidism.
T68 151-290 Sentence denotes He has a previous history of alcoholism and several hospital admissions in the last 3 months on account of infectious respiratory diseases.
T69 291-393 Sentence denotes He came to the hospital on 2 April after 7 days of shortness of breath, fever, asthenia and dry cough.
T70 394-492 Sentence denotes He was in contact with a person who returned from a foreign country, where COVID-19 was extending.
T71 493-716 Sentence denotes Physical examination shows signs of respiratory failure characterized by tachycardia, polypnea, intercostal and supraclavicular muscle retraction, high blood pressure, oxygen saturation of 82%, poor diuresis and drowsiness.
T72 717-815 Sentence denotes Chest x-rays showed bilateral pulmonary inflammatory infiltrates, predominantly in the right lung.
T73 816-968 Sentence denotes Admission ECG showed an atrial fibrillation with rapid ventricular response and the initial gasometry showed severe hypoxemia and respiratory alkalosis.
T74 969-1116 Sentence denotes Patient also had leukocytosis, altered globular sedimentation rate as well as elevated values of AST, LDH, D-dimer and positive C-reactive protein.
T75 1117-1188 Sentence denotes He was admitted into the ICU requiring invasive mechanical ventilation.
T76 1189-1286 Sentence denotes Treatment with lopinavir–ritonavir, chloroquine, IFN α-2b, meropenem and linezolid was initiated.
T77 1287-1486 Sentence denotes 3 days after his admission into the ICU, itolizumab was prescribed, due to worsening of the bilateral pulmonary infiltrates together with a deterioration of the ventilatory function (PO2/FiO2 = 173).
T78 1487-1625 Sentence denotes After the first antibody infusion, PO2/FiO2 significantly increased (PO2/FiO2 = 320) and there were evidences of radiological improvement.
T79 1626-1796 Sentence denotes 3 days after, patient showed radiological worsening of the left lung, characterized by alveolar hypoventilation and atelectasis; then, a 70% pneumothorax was established.
T80 1797-1909 Sentence denotes Treatment of the pneumothorax with minimal pleurotomy was very demanding and required 3 days for the resolution.
T81 1910-2104 Sentence denotes The patient received a second infusion of the monoclonal antibody 72 h after the first, while a third dose was administered at the discretion of the treating physicians, 2 days after the second.
T82 2105-2201 Sentence denotes In total, patient received three doses of itolizumab (200 mg) without any related adverse event.
T83 2202-2316 Sentence denotes IL-6 levels were evaluated before itolizumab administration and after 2, 4 and 7 days of the first administration.
T84 2317-2473 Sentence denotes IL-6 was extremely high at baseline (623 pg/ml) and even though cytokine levels reduced roughly 50%, the lowest value remained above 300 pg/ml after 7 days.
T85 2474-2510 Sentence denotes IL-6 kinetics is shown in Figure 2A.
T86 2511-2584 Sentence denotes Apart from IL-6, IL-1 was undetectable at this time point of the disease.
T87 2585-2678 Sentence denotes Interesting, in the case of AST, a significant reduction is detecting at day 7 (pretreatment:
T88 2679-2691 Sentence denotes 156 U/l, D7:
T89 2692-2726 Sentence denotes 40 U/l) as is showed in Figure 2B.
T90 2727-2874 Sentence denotes After 10 days of admission into the ICU, patient presented a myocardial dysfunction and shock that required vasoactive support with norepinephrine.
T91 2875-2964 Sentence denotes On day 13, he finally died, on account of a mixed cardiovascular and respiratory failure.