PMC:7784786 / 124-1011 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784786","sourcedb":"PMC","sourceid":"7784786","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784786","text":"In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease. Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells. The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis. Its effect is associated with the reduction of pro-inflammatory cytokines release, including IFN-γ, IL-6 and TNF-α. Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access protocol. Itolizumab was able to reduce IL-6 concentrations in all the patients. Two of the three patients showed respiratory and radiological improvement and were fully recovered. We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"24","span":{"begin":165,"end":168},"obj":"Gene"},{"id":"25","span":{"begin":394,"end":399},"obj":"Gene"},{"id":"26","span":{"begin":401,"end":405},"obj":"Gene"},{"id":"27","span":{"begin":410,"end":415},"obj":"Gene"},{"id":"28","span":{"begin":592,"end":596},"obj":"Gene"},{"id":"29","span":{"begin":159,"end":164},"obj":"Species"},{"id":"30","span":{"begin":489,"end":497},"obj":"Species"},{"id":"31","span":{"begin":623,"end":631},"obj":"Species"},{"id":"32","span":{"begin":650,"end":658},"obj":"Species"},{"id":"33","span":{"begin":107,"end":117},"obj":"Chemical"},{"id":"34","span":{"begin":511,"end":521},"obj":"Chemical"},{"id":"35","span":{"begin":562,"end":572},"obj":"Chemical"},{"id":"36","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"37","span":{"begin":290,"end":299},"obj":"Disease"},{"id":"38","span":{"begin":465,"end":479},"obj":"Disease"},{"id":"39","span":{"begin":480,"end":488},"obj":"Disease"},{"id":"40","span":{"begin":843,"end":851},"obj":"Disease"},{"id":"41","span":{"begin":877,"end":886},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:923"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:3458"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:3569"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:7124"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Gene:3569"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:9606"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Tax:9606"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Tax:9606"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Tax:9606"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:C000597346"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:C000597346"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000597346"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D011565"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D016638"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:C000657245"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"MESH:C000657245"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D003643"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"41","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T2","span":{"begin":30,"end":55},"obj":"Phenotype"},{"id":"T3","span":{"begin":290,"end":299},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0003765"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"T4","span":{"begin":107,"end":200},"obj":"Sentence"},{"id":"T5","span":{"begin":201,"end":300},"obj":"Sentence"},{"id":"T6","span":{"begin":301,"end":416},"obj":"Sentence"},{"id":"T7","span":{"begin":417,"end":561},"obj":"Sentence"},{"id":"T8","span":{"begin":562,"end":632},"obj":"Sentence"},{"id":"T9","span":{"begin":633,"end":732},"obj":"Sentence"},{"id":"T10","span":{"begin":733,"end":887},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93d2ec","default":true},{"id":"LitCovid-PD-HP","color":"#ecec93"},{"id":"LitCovid-sentences","color":"#d293ec"}]}]}}