PMC:7784786 / 124-1011 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
24	165-168	Gene	denotes	CD6	Gene:923
25	394-399	Gene	denotes	IFN-γ	Gene:3458
26	401-405	Gene	denotes	IL-6	Gene:3569
27	410-415	Gene	denotes	TNF-α	Gene:7124
28	592-596	Gene	denotes	IL-6	Gene:3569
29	159-164	Species	denotes	human	Tax:9606
30	489-497	Species	denotes	patients	Tax:9606
31	623-631	Species	denotes	patients	Tax:9606
32	650-658	Species	denotes	patients	Tax:9606
33	107-117	Chemical	denotes	Itolizumab	MESH:C000597346
34	511-521	Chemical	denotes	itolizumab	MESH:C000597346
35	562-572	Chemical	denotes	Itolizumab	MESH:C000597346
36	3-11	Disease	denotes	COVID-19	MESH:C000657245
37	290-299	Disease	denotes	psoriasis	MESH:D011565
38	465-479	Disease	denotes	critically ill	MESH:D016638
39	480-488	Disease	denotes	COVID-19	MESH:C000657245
40	843-851	Disease	denotes	COVID-19	MESH:C000657245
41	877-886	Disease	denotes	mortality	MESH:D003643

Id	Subject	Object	Predicate	Lexical cue	hp_id
T2	30-55	Phenotype	denotes	cytokine-release syndrome	http://purl.obolibrary.org/obo/HP_0033041
T3	290-299	Phenotype	denotes	psoriasis	http://purl.obolibrary.org/obo/HP_0003765

Id	Subject	Object	Predicate	Lexical cue
T3	0-106	Sentence	denotes	In COVID-19, the inflammatory cytokine-release syndrome is associated with the progression of the disease.
T4	107-200	Sentence	denotes	Itolizumab is a monoclonal antibody that recognizes human CD6 expressed in activated T cells.
T5	201-300	Sentence	denotes	The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis.
T6	301-416	Sentence	denotes	Its effect is associated with the reduction of pro-inflammatory cytokines release, including IFN-γ, IL-6 and TNF-α.
T7	417-561	Sentence	denotes	Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access protocol.
T8	562-632	Sentence	denotes	Itolizumab was able to reduce IL-6 concentrations in all the patients.
T9	633-732	Sentence	denotes	Two of the three patients showed respiratory and radiological improvement and were fully recovered.
T10	733-887	Sentence	denotes	We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality.