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PMC:7784786 / 10222-11788 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
381 516-524 Gene denotes IFN α-2b Gene:3440
382 1122-1126 Gene denotes IL-6 Gene:3569
383 1199-1203 Gene denotes IL-6 Gene:3569
384 1375-1379 Gene denotes IL-1 Gene:3553
385 1384-1389 Gene denotes TNF-α Gene:7124
386 1471-1474 Gene denotes AST Gene:26503
387 184-191 Species denotes Patient Tax:9606
388 611-618 Species denotes Patient Tax:9606
389 1046-1053 Species denotes Patient Tax:9606
390 1345-1352 Species denotes patient Tax:9606
391 421-427 Chemical denotes Oxygen MESH:D010100
392 466-477 Chemical denotes ceftriaxone MESH:D002443
393 479-498 Chemical denotes lopinavir–ritonavir MESH:C558899
394 500-511 Chemical denotes chloroquine MESH:D002738
395 727-737 Chemical denotes itolizumab MESH:C000597346
396 1307-1317 Chemical denotes itolizumab MESH:C000597346
397 41-49 Disease denotes COVID-19 MESH:C000657245
398 218-230 Disease denotes hypertension MESH:D006973
399 232-249 Disease denotes diabetes mellitus MESH:D003920
400 251-259 Disease denotes glaucoma MESH:D005901
401 310-315 Disease denotes cough MESH:D003371
402 330-338 Disease denotes diarrhea MESH:D003967
403 357-372 Disease denotes viral pneumonia
404 376-384 Disease denotes COVID-19 MESH:C000657245
405 914-934 Disease denotes respiratory distress MESH:D012128

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T43 218-230 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T44 232-249 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 251-259 Phenotype denotes glaucoma http://purl.obolibrary.org/obo/HP_0000501
T46 310-315 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T47 317-325 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T48 330-338 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T49 363-372 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T50 914-934 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T92 0-10 Sentence denotes Patient 3:
T93 11-119 Sentence denotes An 81-year old female, who is COVID-19 positive contact was not identified at the moment of hospitalization.
T94 120-278 Sentence denotes She started symptoms on 2 April and entered the ICU on 5 April. Patient has a previous history of hypertension, diabetes mellitus, glaucoma and smoking habit.
T95 279-339 Sentence denotes She was admitted with frequent cough, wheezing and diarrhea.
T96 340-420 Sentence denotes The diagnosis of viral pneumonia by COVID-19 was confirmed by RT-PCR on 7 April.
T97 421-539 Sentence denotes Oxygen support at 5 l/min and treatment with ceftriaxone, lopinavir–ritonavir, chloroquine and IFN α-2b was indicated.
T98 540-610 Sentence denotes Chest images showed bilateral interstitial infiltration in both lungs.
T99 611-716 Sentence denotes Patient condition was classified as severe, although she did not require invasive mechanical ventilation.
T100 717-798 Sentence denotes A dose of itolizumab (200 mg) was given the day after her admission into the ICU.
T101 799-1045 Sentence denotes Two days after the antibody administration, together with the rest of the therapy, there was an improvement of the respiratory distress while the chest image showed a decrease of the alveolar interstitial infiltrate of both lungs (Figure 1C & D).
T102 1046-1121 Sentence denotes Patient left the ICU after a favorable clinical and radiological evolution.
T103 1122-1198 Sentence denotes IL-6 concentration was measured prior and after the antibody administration.
T104 1199-1374 Sentence denotes IL-6 level at baseline was lower than in previous cases (30 pg/ml), but also decreased 48 h and 168 h after itolizumab infusion, in parallel with patient recovery (Figure 2A).
T105 1375-1457 Sentence denotes IL-1 and TNF-α were untraceable before and 48 h after the antibody administration.
T106 1458-1566 Sentence denotes Regarding to AST concentration, the values were in the normal range during the treatment period (Figure 2B).