PMC:7781431 / 7633-8706 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"233","span":{"begin":141,"end":146},"obj":"Gene"},{"id":"234","span":{"begin":302,"end":307},"obj":"Gene"},{"id":"235","span":{"begin":62,"end":65},"obj":"Chemical"},{"id":"236","span":{"begin":162,"end":169},"obj":"Chemical"},{"id":"237","span":{"begin":211,"end":217},"obj":"Chemical"},{"id":"238","span":{"begin":230,"end":270},"obj":"Chemical"},{"id":"239","span":{"begin":272,"end":280},"obj":"Chemical"},{"id":"240","span":{"begin":319,"end":327},"obj":"Chemical"},{"id":"241","span":{"begin":331,"end":352},"obj":"Chemical"},{"id":"251","span":{"begin":1001,"end":1006},"obj":"Gene"},{"id":"252","span":{"begin":1011,"end":1025},"obj":"Gene"},{"id":"253","span":{"begin":466,"end":471},"obj":"Gene"},{"id":"254","span":{"begin":878,"end":881},"obj":"Species"},{"id":"255","span":{"begin":445,"end":453},"obj":"Chemical"},{"id":"256","span":{"begin":475,"end":505},"obj":"Chemical"},{"id":"257","span":{"begin":590,"end":597},"obj":"Chemical"},{"id":"258","span":{"begin":1032,"end":1040},"obj":"Chemical"},{"id":"259","span":{"begin":768,"end":780},"obj":"Disease"}],"attributes":[{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Gene:5743"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"Gene:240"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D015118"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:D001241"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"MESH:D010100"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Gene:240"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"Gene:299732"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"Gene:240"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"Tax:10116"},{"id":"A259","pred":"tao:has_database_id","subj":"259","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"E-series resolvins\nRvE is a di- or tri-hydroxyl metabolite of EPA. To date, four RvEs (RvE1, 18S-RvE1, RvE2, and RvE3) have been discovered. COX-2, acetylated by aspirin in hypoxic endothelial cells, introduces oxygen groups into 18R-hydro (peroxy)-eicosapentaenoic acid (18R-HEPE). Activated PMN uses 5-LOX to convert 18R-HEPE to 5S (6)-epoxy-18R-HEPE, which is further hydrolyzed to RvE1 (Serhan et al. 2000).\nRvE2 is produced by reduction of 18R HEPE products by 5-LOX to 5S-hydroperoxy, 18-hydroxy-EPE in whole blood (Oh et al. 2012). Unlike RvE1, RvE2 and RvE3 are biosynthesized from 18-HEPE via the 12/15-LOX pathway in eosinophils (Isobe et al. 2012b). Endogenous RvE1 has been shown to accumulate for between 48 and 72 hours, which is a delayed time point of inflammation (Hong et al. 2008). RvE2 appeared at the time point corresponding to initial PMN infiltration in rat peritoneal exudate stimulated by zymosan A and decreased within 24 hours (Isobe et al. 2012a). 18S-RvE1 is produced by 5-LOX and LTA4 hydrolase using 18S-HEPE as a substrate (Oh et al. 2011)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T54","span":{"begin":19,"end":66},"obj":"Sentence"},{"id":"T55","span":{"begin":67,"end":140},"obj":"Sentence"},{"id":"T56","span":{"begin":141,"end":282},"obj":"Sentence"},{"id":"T57","span":{"begin":283,"end":404},"obj":"Sentence"},{"id":"T58","span":{"begin":405,"end":411},"obj":"Sentence"},{"id":"T59","span":{"begin":412,"end":531},"obj":"Sentence"},{"id":"T60","span":{"begin":532,"end":538},"obj":"Sentence"},{"id":"T61","span":{"begin":539,"end":652},"obj":"Sentence"},{"id":"T62","span":{"begin":653,"end":660},"obj":"Sentence"},{"id":"T63","span":{"begin":661,"end":793},"obj":"Sentence"},{"id":"T64","span":{"begin":794,"end":800},"obj":"Sentence"},{"id":"T65","span":{"begin":801,"end":968},"obj":"Sentence"},{"id":"T66","span":{"begin":969,"end":976},"obj":"Sentence"},{"id":"T67","span":{"begin":977,"end":1066},"obj":"Sentence"},{"id":"T68","span":{"begin":1067,"end":1073},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"E-series resolvins\nRvE is a di- or tri-hydroxyl metabolite of EPA. To date, four RvEs (RvE1, 18S-RvE1, RvE2, and RvE3) have been discovered. COX-2, acetylated by aspirin in hypoxic endothelial cells, introduces oxygen groups into 18R-hydro (peroxy)-eicosapentaenoic acid (18R-HEPE). Activated PMN uses 5-LOX to convert 18R-HEPE to 5S (6)-epoxy-18R-HEPE, which is further hydrolyzed to RvE1 (Serhan et al. 2000).\nRvE2 is produced by reduction of 18R HEPE products by 5-LOX to 5S-hydroperoxy, 18-hydroxy-EPE in whole blood (Oh et al. 2012). Unlike RvE1, RvE2 and RvE3 are biosynthesized from 18-HEPE via the 12/15-LOX pathway in eosinophils (Isobe et al. 2012b). Endogenous RvE1 has been shown to accumulate for between 48 and 72 hours, which is a delayed time point of inflammation (Hong et al. 2008). RvE2 appeared at the time point corresponding to initial PMN infiltration in rat peritoneal exudate stimulated by zymosan A and decreased within 24 hours (Isobe et al. 2012a). 18S-RvE1 is produced by 5-LOX and LTA4 hydrolase using 18S-HEPE as a substrate (Oh et al. 2011)."}