PMC:7781431 / 6412-7631 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"Resolvin (Rv) is a pro-resolving mediator that is derived from omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and clupanodonic acid (Duvall and Levy 2016; Serhan et al. 2014). Rvs are divided into several subclasses based on the unique aspects of their structure and/or the straight-chain PUFAs from which they are formed. Resolvin Ds (RvDs) are metabolites of 22-carbon PUFA, DHA. Resolvin Es (RvE) are metabolites of 20 carbons PUFA, EPA; Resolvin Dn-6DPA (RvDn-6DPA) is a DPA isomer, a metabolite of osbond acids; Resolvin Dn-3DPA (RvDn-3DPA) is a DPA isomer, a metabolite of clupanodonic acid; Resolvin Ts (RvT) is a metabolite of clupanodonic acid with 17R-hydroxyl residues, unlike RvDsn-3DPA (all have 17S-hydroxyl residues). AT-RvDs, RvD isomers are synthesized by the aspirin-modified COX-2 enzyme to form 17 (R)-hydroxyl rather than the 17 (S)-hydroxyl residue of RvE. Cytochrome P450 enzymes that have not yet been characterized may also form this 17 (R)-hydroxy intermediate and contribute to the production of AT-RvE. All mentioned Rvs except RvDsn-6DPA are metabolites of omega-3 fatty acids (Serhan et al. 2014; Duvall and Levy 2016).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"210","span":{"begin":441,"end":445},"obj":"Gene"},{"id":"211","span":{"begin":500,"end":504},"obj":"Gene"},{"id":"212","span":{"begin":864,"end":869},"obj":"Gene"},{"id":"213","span":{"begin":63,"end":82},"obj":"Chemical"},{"id":"214","span":{"begin":94,"end":115},"obj":"Chemical"},{"id":"215","span":{"begin":117,"end":120},"obj":"Chemical"},{"id":"216","span":{"begin":123,"end":143},"obj":"Chemical"},{"id":"217","span":{"begin":145,"end":148},"obj":"Chemical"},{"id":"218","span":{"begin":151,"end":172},"obj":"Chemical"},{"id":"219","span":{"begin":174,"end":177},"obj":"Chemical"},{"id":"220","span":{"begin":184,"end":201},"obj":"Chemical"},{"id":"221","span":{"begin":447,"end":450},"obj":"Chemical"},{"id":"222","span":{"begin":847,"end":854},"obj":"Chemical"},{"id":"223","span":{"begin":1156,"end":1175},"obj":"Chemical"}],"attributes":[{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Gene:9933"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"Gene:9933"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"Gene:5743"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D015525"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"MESH:D015118"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"MESH:D015118"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"MESH:D004281"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"MESH:D004281"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"MESH:C026219"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"MESH:C026219"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"MESH:C026219"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"MESH:D004281"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"MESH:D001241"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D015525"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"212","pred":"source","obj":"LitCovid-PubTator"},{"subj":"213","pred":"source","obj":"LitCovid-PubTator"},{"subj":"214","pred":"source","obj":"LitCovid-PubTator"},{"subj":"215","pred":"source","obj":"LitCovid-PubTator"},{"subj":"216","pred":"source","obj":"LitCovid-PubTator"},{"subj":"217","pred":"source","obj":"LitCovid-PubTator"},{"subj":"218","pred":"source","obj":"LitCovid-PubTator"},{"subj":"219","pred":"source","obj":"LitCovid-PubTator"},{"subj":"220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"221","pred":"source","obj":"LitCovid-PubTator"},{"subj":"222","pred":"source","obj":"LitCovid-PubTator"},{"subj":"223","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T44","span":{"begin":0,"end":238},"obj":"Sentence"},{"id":"T45","span":{"begin":239,"end":245},"obj":"Sentence"},{"id":"T46","span":{"begin":246,"end":392},"obj":"Sentence"},{"id":"T47","span":{"begin":393,"end":451},"obj":"Sentence"},{"id":"T48","span":{"begin":452,"end":802},"obj":"Sentence"},{"id":"T49","span":{"begin":803,"end":948},"obj":"Sentence"},{"id":"T50","span":{"begin":949,"end":1100},"obj":"Sentence"},{"id":"T51","span":{"begin":1101,"end":1190},"obj":"Sentence"},{"id":"T52","span":{"begin":1191,"end":1219},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecb893","default":true},{"id":"LitCovid-sentences","color":"#9d93ec"}]}]}}