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PMC:7781431 / 30047-34443 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
851 0-27 Species denotes Respiratory syncytial virus Tax:12814
852 29-57 Species denotes human immunodeficiency virus Tax:12721
853 63-80 Disease denotes hepatitis C virus MESH:D006526
877 736-741 Gene denotes COX-2 Gene:5743
878 1085-1089 Gene denotes FPR2 Gene:2358
879 1090-1093 Gene denotes ALX Gene:84941
880 1098-1103 Gene denotes GPR32 Gene:2854
881 81-108 Species denotes Respiratory syncytial virus Tax:12814
882 130-135 Species denotes human Tax:9606
883 167-171 Species denotes HRSV Tax:11250
884 177-199 Species denotes human orthopneumovirus Tax:11250
885 136-147 Species denotes respiratory Tax:12814
886 1014-1025 Species denotes respiratory Tax:12814
887 110-113 Species denotes RSV Tax:12814
888 465-468 Species denotes RSV Tax:12814
889 724-727 Species denotes RSV Tax:12814
890 1042-1045 Species denotes RSV Tax:12814
891 1230-1233 Species denotes RSV Tax:12814
892 948-979 Chemical denotes polyinosinic-polycytidylic acid MESH:D011070
893 1177-1182 Chemical denotes lipid MESH:D008055
894 224-246 Disease denotes respiratory infections MESH:D012141
895 256-264 Disease denotes infected MESH:D007239
896 368-396 Disease denotes respiratory tract infections MESH:D012141
897 469-478 Disease denotes infection MESH:D007239
898 490-503 Disease denotes bronchiolitis MESH:D001988
899 1267-1276 Disease denotes infection MESH:D007239
910 1288-1316 Species denotes Human immunodeficiency virus Tax:12721
911 1452-1457 Species denotes HIV-1 Tax:11676
912 1462-1467 Species denotes HIV-2 Tax:11709
913 1318-1321 Species denotes HIV Tax:12721
914 1469-1482 Disease denotes HIV infection MESH:D015658
915 1508-1533 Disease denotes immunodeficiency syndrome MESH:D007153
916 1535-1539 Disease denotes AIDS MESH:D000163
917 1597-1601 Disease denotes AIDS MESH:D000163
918 1626-1650 Disease denotes opportunistic infections MESH:D009894
919 1676-1682 Disease denotes cancer MESH:D009369
935 1889-1894 Gene denotes TNF-α Gene:7124
936 1900-1914 Gene denotes interleukin-1β Gene:3553
937 2308-2313 Gene denotes gp120 Gene:3700
938 2348-2352 Gene denotes FPR2 Gene:2358
939 2353-2356 Gene denotes ALX Gene:84941
940 2425-2429 Gene denotes CCR5 Gene:1234
941 2434-2439 Gene denotes CXCR4 Gene:7852
942 1791-1796 Species denotes human Tax:9606
943 1841-1846 Species denotes human Tax:9606
944 2272-2307 Species denotes human immunodeficiency virus type 1 Tax:11676
945 1754-1768 Disease denotes HIV-1 infected MESH:D015658
946 1810-1821 Disease denotes astrocytoma MESH:D001254
947 1859-1874 Disease denotes tumour necrosis MESH:D009336
948 2147-2162 Disease denotes viral infection MESH:D001102
949 2197-2206 Disease denotes infection MESH:D007239
969 2473-2477 Gene denotes FPR2 Gene:2358
970 2478-2481 Gene denotes ALX Gene:84941
971 2630-2634 Gene denotes CCR3 Gene:1232
972 2639-2643 Gene denotes FPR2 Gene:2358
973 2644-2647 Gene denotes ALX Gene:84941
974 2723-2726 Gene denotes Env Gene:100616444
975 2779-2783 Gene denotes FPR2 Gene:2358
976 2806-2810 Gene denotes CCR3 Gene:1232
977 2835-2842 Gene denotes ChemR23 Gene:1240
978 2967-2974 Gene denotes ChemR23 Gene:1240
979 3111-3115 Gene denotes FPR2 Gene:2358
980 3120-3127 Gene denotes ChemR23 Gene:1240
981 2885-2890 Species denotes HIV-1 Tax:11676
982 2895-2900 Species denotes HIV-2 Tax:11709
983 2544-2547 Species denotes HIV Tax:12721
984 2662-2665 Species denotes HIV Tax:12721
985 2866-2869 Species denotes HIV Tax:12721
986 2982-2991 Disease denotes infection MESH:D007239
987 3131-3144 Disease denotes HIV infection MESH:D015658
1018 3860-3865 Gene denotes GPR37 Gene:2861
1019 3987-3992 Gene denotes GPR37 Gene:2861
1020 4166-4170 Gene denotes FPR2 Gene:2358
1021 4171-4174 Gene denotes ALX Gene:84941
1022 4320-4323 Gene denotes SAA Gene:6287
1023 3587-3590 Gene denotes C5A Gene:728
1024 4371-4374 Gene denotes SAA Gene:6287
1025 4073-4076 Gene denotes SAA Gene:6287
1026 3146-3163 Species denotes Hepatitis C virus Tax:11103
1027 3434-3440 Species denotes humans Tax:9606
1028 3471-3476 Species denotes Lemon Tax:2708
1029 3684-3689 Species denotes human Tax:9606
1030 3165-3168 Species denotes HCV Tax:11103
1031 3304-3307 Species denotes HCV Tax:11103
1032 3560-3563 Species denotes HCV Tax:11103
1033 3574-3577 Species denotes HCV Tax:11103
1034 3627-3630 Species denotes HCV Tax:11103
1035 3806-3809 Species denotes HCV Tax:11103
1036 3841-3844 Species denotes HCV Tax:11103
1037 4059-4062 Species denotes HCV Tax:11103
1038 4112-4115 Species denotes HCV Tax:11103
1039 3811-3820 Chemical denotes Vitamin D MESH:D014807
1040 3345-3352 Disease denotes cancers MESH:D009369
1041 3361-3373 Disease denotes liver cancer MESH:D006528
1042 3375-3399 Disease denotes hepatocellular carcinoma MESH:D006528
1043 3422-3430 Disease denotes lymphoma MESH:D008223
1044 4145-4157 Disease denotes inflammation MESH:D007249
1045 4184-4196 Disease denotes liver damage MESH:D056486
1046 4348-4360 Disease denotes liver damage MESH:D056486
1047 4382-4395 Disease denotes HCV infection MESH:D006526

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T25 35-51 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T26 63-72 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T27 224-246 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T28 362-396 Phenotype denotes lower respiratory tract infections http://purl.obolibrary.org/obo/HP_0002783
T29 490-503 Phenotype denotes bronchiolitis http://purl.obolibrary.org/obo/HP_0011950
T30 1294-1310 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T31 1508-1524 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T32 1626-1650 Phenotype denotes opportunistic infections http://purl.obolibrary.org/obo/HP_0031690
T33 1676-1682 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T34 1810-1821 Phenotype denotes astrocytoma http://purl.obolibrary.org/obo/HP_0009592
T35 1859-1865 Phenotype denotes tumour http://purl.obolibrary.org/obo/HP_0002664
T36 2278-2294 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T37 3146-3155 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115
T38 3324-3333 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T39 3361-3373 Phenotype denotes liver cancer http://purl.obolibrary.org/obo/HP_0002896
T40 3375-3399 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T41 3422-3430 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T299 0-80 Sentence denotes Respiratory syncytial virus, human immunodeficiency virus, and hepatitis C virus
T300 81-334 Sentence denotes Respiratory syncytial virus (RSV), also known as human respiratory cell fusion virus (HRSV) and human orthopneumovirus, is a virus that causes respiratory infections in which infected mucosal cells fuse to form a syncytium (Schweitzer and Justice 2020).
T301 335-464 Sentence denotes It is the leading cause of lower respiratory tract infections and hospital visits in infancy and childhood (Read and Bosco 2020).
T302 465-635 Sentence denotes RSV infection results in bronchiolitis, which is classically caused by activated macrophages and eventually resolved by alternatively activated macrophages (Shirey et al.
T303 636-642 Sentence denotes 2010).
T304 643-816 Sentence denotes The promotion of these two alternative macrophage fates appears to be related to RSV-induced COX-2 and LXA4 and RvE1-mediated protective measures (Fig. 4) (Richardson et al.
T305 817-836 Sentence denotes 2005; Shirey et al.
T306 837-843 Sentence denotes 2014).
T307 844-1117 Sentence denotes Also, although it does not directly act on the virus, RvD1 inhibits inflammatory signal transduction by polyinosinic-polycytidylic acid, an analogue of RNAs derived from respiratory viruses such as RSV, and the action of RvD1 is mediated by FPR2/ALX and GPR32 (Hsiao et al.
T308 1118-1124 Sentence denotes 2014).
T309 1125-1287 Sentence denotes These reports suggest the critical role of SPMs and lipid mediator class shift in the host’s response to RSV in the initial control and final infection clearance.
T310 1288-1468 Sentence denotes Human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retroviruses) and are classified into two based on the genetic characteristics and viral antigen, HIV-1 and HIV-2.
T311 1469-1585 Sentence denotes HIV infection may progress to acquired immunodeficiency syndrome (AIDS), a progressive failure of the immune system.
T312 1586-1704 Sentence denotes Over time, AIDS causes life-threatening opportunistic infections and a condition in which cancer thrives (Douek et al.
T313 1705-1724 Sentence denotes 2009; Powell et al.
T314 1725-1731 Sentence denotes 2016).
T315 1732-2045 Sentence denotes When co-cultured with HIV-1 infected mononuclear cells and human glial cells (astrocytoma, glial and primary human astrocyte), tumour necrosis factor alpha (TNF-α) and interleukin-1β are produced, and large amounts of LTB4, LTD4, LXA4, and PAF, were also found in media from this co-culture (Fig. 4) (Genis et al.
T316 2046-2052 Sentence denotes 1992).
T317 2053-2163 Sentence denotes So far, this is the only in vitro study to prove, that LXs are produced in direct response to viral infection.
T318 2164-2239 Sentence denotes However, the role of LXs in this infection model has not been investigated.
T319 2240-2465 Sentence denotes Synthetic peptides derived from human immunodeficiency virus type 1 gp120 activate the 7-transmembrane GPCR FPR2/ALX, down-regulating the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes (Deng et al.
T320 2466-2472 Sentence denotes 1999).
T321 2473-2563 Sentence denotes FPR2/ALX acts as an efficient core receptor for the primary isolate of HIV (Shimizu et al.
T322 2564-2570 Sentence denotes 2008).
T323 2571-2681 Sentence denotes Viral entries through the alternative core receptors (CoR) CCR3 and FPR2/ALX depend on the HIV type 1 subtype.
T324 2682-2827 Sentence denotes Viruses pseudotyped with subtype A and C Env proteins use the recently described alternative CoR FPR2 more efficiently than CCR3 (Nedellec et al.
T325 2828-2834 Sentence denotes 2009).
T326 2835-2870 Sentence denotes ChemR23 also acts as a CoR for HIV.
T327 2871-3010 Sentence denotes At this time, HIV-1 and HIV-2 appear to use the N-terminus and the second extracellular loop of ChemR23 during infection (Martensson et al.
T328 3011-3017 Sentence denotes 2006).
T329 3018-3145 Sentence denotes As mentioned above, research is needed to determine the role of SPMs that act as ligands for FPR2 and ChemR23 in HIV infection.
T330 3146-3292 Sentence denotes Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus of the family Flaviviridae with a small (55–65 nm size) envelope (Lee et al.
T331 3293-3299 Sentence denotes 2017).
T332 3300-3454 Sentence denotes The HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma, abbreviated HCC) and lymphoma in humans (Ferri et al.
T333 3455-3483 Sentence denotes 2015; Rusyn and Lemon 2014).
T334 3484-3564 Sentence denotes To date, there appears to be no report on the effectiveness of SPMs against HCV.
T335 3565-3712 Sentence denotes However, HCV peptide (C5A), an amphiphilic α-helix peptide of HCV, is an activator of the N-formyl peptide receptor in human phagocytes (Lin et al.
T336 3713-3719 Sentence denotes 2011).
T337 3720-3810 Sentence denotes This suggests the possibility of interaction between RvD1 and LXA4, FPR families, and HCV.
T338 3811-3933 Sentence denotes Vitamin D metabolites inhibit HCV and upregulate GPR37 gene expression, which induces cellular autophagy (Gutierrez et al.
T339 3934-3940 Sentence denotes 2014).
T340 3941-4072 Sentence denotes PD1 was recently proposed as a new ligand for GPR37, and some studies suggest a possible relationship between PD1 and HCV (Fig. 4).
T341 4073-4223 Sentence denotes SAA also has antiviral effects against HCV, however, it induces chronic inflammation through FPR2/ALX, causing liver damage (Abouelasrar Salama et al.
T342 4224-4230 Sentence denotes 2019).
T343 4231-4396 Sentence denotes Although research has not been conducted yet, RvD1 and LXA4, which inhibit the action of SAA, are likely to suppress liver damage caused by SAA during HCV infection.