PMC:7781431 / 28687-30045
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"Herpes simplex virus\nHerpesviruses 1 and 2 (HSV-1 and HSV-2), with the taxonomic names human alphaherpesvirus 1 and human alphaherpesvirus 2, are the most common causes of human viral infections among the members of the human Herpesviridae family (Chayavichitsilp et al. 2009). Herpes simplex virus (HSV) ocular infection represents another example in which local control of the virus stems from a robust inflammatory response with long-term consequences of chronic inflammation, including the possibility of final blindness due to interstitial keratitis that persists even after the viral infection has been cleared.\nIn animals with HSV, topical administration of RvE1 reduced the influx of CD4+ T cells (both TH1 cells and TH17 cells) and neutrophils, decreased production of inflammatory cytokines including IFNγ and IL-6, and increased levels of the anti-inflammatory cytokine IL-10 (Fig. 4) (Rajasagi et al. 2011). Overall, RvE1 significantly reduced stromal keratitis. Similar results were demonstrated with PD1 (Fig. 4) (Rajasagi et al. 2013). Besides, AT-RvD1 treatment significantly reduced the degree of corneal angiogenesis and the severity of stromal keratitis lesions, and AT-RvD1 treated mice had fewer Th1 and Th17 cells in the infected cornea, as well as the reduced number of inflammatory cells, including neutrophils (Rajasagi et al. 2017).","divisions":[{"label":"title","span":{"begin":0,"end":20}},{"label":"p","span":{"begin":21,"end":617}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"816","span":{"begin":21,"end":42},"obj":"Gene"},{"id":"817","span":{"begin":44,"end":49},"obj":"Species"},{"id":"818","span":{"begin":54,"end":59},"obj":"Species"},{"id":"819","span":{"begin":87,"end":111},"obj":"Species"},{"id":"820","span":{"begin":116,"end":140},"obj":"Species"},{"id":"821","span":{"begin":172,"end":177},"obj":"Species"},{"id":"822","span":{"begin":220,"end":225},"obj":"Species"},{"id":"823","span":{"begin":178,"end":194},"obj":"Disease"},{"id":"824","span":{"begin":248,"end":263},"obj":"Disease"},{"id":"825","span":{"begin":312,"end":321},"obj":"Disease"},{"id":"826","span":{"begin":466,"end":478},"obj":"Disease"},{"id":"827","span":{"begin":515,"end":524},"obj":"Disease"},{"id":"828","span":{"begin":545,"end":554},"obj":"Disease"},{"id":"829","span":{"begin":584,"end":599},"obj":"Disease"},{"id":"839","span":{"begin":692,"end":695},"obj":"Gene"},{"id":"840","span":{"begin":811,"end":815},"obj":"Gene"},{"id":"841","span":{"begin":820,"end":824},"obj":"Gene"},{"id":"842","span":{"begin":881,"end":886},"obj":"Gene"},{"id":"843","span":{"begin":1202,"end":1206},"obj":"Species"},{"id":"844","span":{"begin":964,"end":973},"obj":"Disease"},{"id":"845","span":{"begin":1114,"end":1121},"obj":"Disease"},{"id":"846","span":{"begin":1163,"end":1180},"obj":"Disease"},{"id":"847","span":{"begin":1243,"end":1251},"obj":"Disease"}],"attributes":[{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"Tax:10298"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"Tax:10310"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Tax:10298"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Tax:10310"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Tax:9606"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Tax:9606"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"MESH:D001102"},{"id":"A825","pred":"tao:has_database_id","subj":"825","obj":"MESH:D007239"},{"id":"A826","pred":"tao:has_database_id","subj":"826","obj":"MESH:D007249"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"MESH:D001766"},{"id":"A828","pred":"tao:has_database_id","subj":"828","obj":"MESH:D007634"},{"id":"A829","pred":"tao:has_database_id","subj":"829","obj":"MESH:D001102"},{"id":"A839","pred":"tao:has_database_id","subj":"839","obj":"Gene:920"},{"id":"A840","pred":"tao:has_database_id","subj":"840","obj":"Gene:3458"},{"id":"A841","pred":"tao:has_database_id","subj":"841","obj":"Gene:3569"},{"id":"A842","pred":"tao:has_database_id","subj":"842","obj":"Gene:3586"},{"id":"A843","pred":"tao:has_database_id","subj":"843","obj":"Tax:10090"},{"id":"A844","pred":"tao:has_database_id","subj":"844","obj":"MESH:D007634"},{"id":"A845","pred":"tao:has_database_id","subj":"845","obj":"MESH:D003316"},{"id":"A846","pred":"tao:has_database_id","subj":"846","obj":"MESH:D007634"},{"id":"A847","pred":"tao:has_database_id","subj":"847","obj":"MESH:D007239"},{"subj":"816","pred":"source","obj":"LitCovid-PubTator"},{"subj":"817","pred":"source","obj":"LitCovid-PubTator"},{"subj":"818","pred":"source","obj":"LitCovid-PubTator"},{"subj":"819","pred":"source","obj":"LitCovid-PubTator"},{"subj":"820","pred":"source","obj":"LitCovid-PubTator"},{"subj":"821","pred":"source","obj":"LitCovid-PubTator"},{"subj":"822","pred":"source","obj":"LitCovid-PubTator"},{"subj":"823","pred":"source","obj":"LitCovid-PubTator"},{"subj":"824","pred":"source","obj":"LitCovid-PubTator"},{"subj":"825","pred":"source","obj":"LitCovid-PubTator"},{"subj":"826","pred":"source","obj":"LitCovid-PubTator"},{"subj":"827","pred":"source","obj":"LitCovid-PubTator"},{"subj":"828","pred":"source","obj":"LitCovid-PubTator"},{"subj":"829","pred":"source","obj":"LitCovid-PubTator"},{"subj":"839","pred":"source","obj":"LitCovid-PubTator"},{"subj":"840","pred":"source","obj":"LitCovid-PubTator"},{"subj":"841","pred":"source","obj":"LitCovid-PubTator"},{"subj":"842","pred":"source","obj":"LitCovid-PubTator"},{"subj":"843","pred":"source","obj":"LitCovid-PubTator"},{"subj":"844","pred":"source","obj":"LitCovid-PubTator"},{"subj":"845","pred":"source","obj":"LitCovid-PubTator"},{"subj":"846","pred":"source","obj":"LitCovid-PubTator"},{"subj":"847","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T21","span":{"begin":515,"end":524},"obj":"Phenotype"},{"id":"T22","span":{"begin":545,"end":554},"obj":"Phenotype"},{"id":"T23","span":{"begin":964,"end":973},"obj":"Phenotype"},{"id":"T24","span":{"begin":1163,"end":1172},"obj":"Phenotype"}],"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