PMC:7781431 / 26296-27260 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"Annexin is the most abundant host cell protein in the virion, and annexin A1 (ANXA1) contributes to influenza-induced toxicity (Tcherniuk et al. 2016). That is, during virus entry into the host cell, viral hemagglutinin (HA) not only binds sialic acid but also ANXA1 binds to FPR2, resulting in activation of ERK2 and increased viral replication (Tcherniuk et al. 2016). RvD1 and LXA4 also activate FPR2. It is still unknown whether RvD1 and LXA4 compete with viral annexin at the receptors site leads to the prevention of viral infection or the promotion of viral replication. However, it is reported that AT-RvD1 reduces inflammation caused by the viral infection. (Wang et al. 2017). Increased SAA in recurrent acute exacerbations of COPD caused by bacterial and virus coinfection acts as a functional agonist of FPR2/ALX, antagonizing the protective action of FPR2/ALX by AT-RvD1, promoting chemotaxis of neutrophils and prolonging survival (Wang et al. 2018).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"747","span":{"begin":66,"end":76},"obj":"Gene"},{"id":"748","span":{"begin":78,"end":83},"obj":"Gene"},{"id":"749","span":{"begin":261,"end":266},"obj":"Gene"},{"id":"750","span":{"begin":276,"end":280},"obj":"Gene"},{"id":"751","span":{"begin":309,"end":313},"obj":"Gene"},{"id":"752","span":{"begin":399,"end":403},"obj":"Gene"},{"id":"753","span":{"begin":697,"end":700},"obj":"Gene"},{"id":"754","span":{"begin":816,"end":820},"obj":"Gene"},{"id":"755","span":{"begin":821,"end":824},"obj":"Gene"},{"id":"756","span":{"begin":864,"end":868},"obj":"Gene"},{"id":"757","span":{"begin":869,"end":872},"obj":"Gene"},{"id":"758","span":{"begin":100,"end":109},"obj":"Species"},{"id":"759","span":{"begin":240,"end":251},"obj":"Chemical"},{"id":"760","span":{"begin":118,"end":126},"obj":"Disease"},{"id":"761","span":{"begin":523,"end":538},"obj":"Disease"},{"id":"762","span":{"begin":623,"end":635},"obj":"Disease"},{"id":"763","span":{"begin":650,"end":665},"obj":"Disease"},{"id":"764","span":{"begin":737,"end":741},"obj":"Disease"},{"id":"765","span":{"begin":766,"end":788},"obj":"Disease"}],"attributes":[{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Gene:301"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"Gene:301"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Gene:301"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:2358"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Gene:5594"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:2358"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"Gene:6287"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:2358"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:84941"},{"id":"A756","pred":"tao:has_database_id","subj":"756","obj":"Gene:2358"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"Gene:84941"},{"id":"A758","pred":"tao:has_database_id","subj":"758","obj":"Tax:11320"},{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"MESH:D019158"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"MESH:D064420"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"MESH:D001102"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"MESH:D007249"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"MESH:D001102"},{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"MESH:D029424"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"MESH:D060085"},{"subj":"747","pred":"source","obj":"LitCovid-PubTator"},{"subj":"748","pred":"source","obj":"LitCovid-PubTator"},{"subj":"749","pred":"source","obj":"LitCovid-PubTator"},{"subj":"750","pred":"source","obj":"LitCovid-PubTator"},{"subj":"751","pred":"source","obj":"LitCovid-PubTator"},{"subj":"752","pred":"source","obj":"LitCovid-PubTator"},{"subj":"753","pred":"source","obj":"LitCovid-PubTator"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"},{"subj":"756","pred":"source","obj":"LitCovid-PubTator"},{"subj":"757","pred":"source","obj":"LitCovid-PubTator"},{"subj":"758","pred":"source","obj":"LitCovid-PubTator"},{"subj":"759","pred":"source","obj":"LitCovid-PubTator"},{"subj":"760","pred":"source","obj":"LitCovid-PubTator"},{"subj":"761","pred":"source","obj":"LitCovid-PubTator"},{"subj":"762","pred":"source","obj":"LitCovid-PubTator"},{"subj":"763","pred":"source","obj":"LitCovid-PubTator"},{"subj":"764","pred":"source","obj":"LitCovid-PubTator"},{"subj":"765","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":737,"end":741},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T262","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T263","span":{"begin":145,"end":151},"obj":"Sentence"},{"id":"T264","span":{"begin":152,"end":363},"obj":"Sentence"},{"id":"T265","span":{"begin":364,"end":370},"obj":"Sentence"},{"id":"T266","span":{"begin":371,"end":404},"obj":"Sentence"},{"id":"T267","span":{"begin":405,"end":577},"obj":"Sentence"},{"id":"T268","span":{"begin":578,"end":679},"obj":"Sentence"},{"id":"T269","span":{"begin":680,"end":686},"obj":"Sentence"},{"id":"T270","span":{"begin":687,"end":957},"obj":"Sentence"},{"id":"T271","span":{"begin":958,"end":964},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T26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