PMC:7781431 / 15867-16584 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"439","span":{"begin":11,"end":15},"obj":"Gene"},{"id":"440","span":{"begin":139,"end":143},"obj":"Gene"},{"id":"441","span":{"begin":196,"end":200},"obj":"Gene"},{"id":"442","span":{"begin":201,"end":204},"obj":"Gene"},{"id":"443","span":{"begin":252,"end":256},"obj":"Gene"},{"id":"444","span":{"begin":257,"end":260},"obj":"Gene"},{"id":"445","span":{"begin":111,"end":137},"obj":"Chemical"},{"id":"446","span":{"begin":348,"end":350},"obj":"Chemical"},{"id":"447","span":{"begin":439,"end":443},"obj":"Chemical"},{"id":"448","span":{"begin":572,"end":578},"obj":"Chemical"},{"id":"449","span":{"begin":525,"end":538},"obj":"Disease"}],"attributes":[{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Gene:2358"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Gene:2357"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Gene:2358"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Gene:84941"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Gene:2358"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Gene:84941"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:D014316"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"MESH:C040527"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Originally FPR2 was classified as an FPR receptor due to its activation by the low-affinity endogenous agonist N-formyl methionyl peptide (fMLP) (Ye et al. 1992). The receptor was reclassified as FPR2/ALX, as LXA4 exhibited the highest affinity of all FPR2/ALX endogenous agonists through screening of various receptor ligands using radiolabelled [3H]-LXA4 and subsequent GTPase activity (Fiore et al. 1994; Brink et al. 2003). Binding of LXA4 leads to the stimulation of monocyte chemotaxis, macrophage differentiation, and efferocytosis (Maderna et al. 2010; Maddox and Serhan 1996). LXA4 also reduces the adaptive immune response by reducing memory B cell antibody production and proliferation (Ramon et al. 2014)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T152","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T153","span":{"begin":156,"end":162},"obj":"Sentence"},{"id":"T154","span":{"begin":163,"end":401},"obj":"Sentence"},{"id":"T155","span":{"begin":402,"end":420},"obj":"Sentence"},{"id":"T156","span":{"begin":421,"end":427},"obj":"Sentence"},{"id":"T157","span":{"begin":428,"end":554},"obj":"Sentence"},{"id":"T158","span":{"begin":555,"end":585},"obj":"Sentence"},{"id":"T159","span":{"begin":586,"end":710},"obj":"Sentence"},{"id":"T160","span":{"begin":711,"end":717},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Originally FPR2 was classified as an FPR receptor due to its activation by the low-affinity endogenous agonist N-formyl methionyl peptide (fMLP) (Ye et al. 1992). The receptor was reclassified as FPR2/ALX, as LXA4 exhibited the highest affinity of all FPR2/ALX endogenous agonists through screening of various receptor ligands using radiolabelled [3H]-LXA4 and subsequent GTPase activity (Fiore et al. 1994; Brink et al. 2003). Binding of LXA4 leads to the stimulation of monocyte chemotaxis, macrophage differentiation, and efferocytosis (Maderna et al. 2010; Maddox and Serhan 1996). LXA4 also reduces the adaptive immune response by reducing memory B cell antibody production and proliferation (Ramon et al. 2014)."}