PMC:7781431 / 15813-17106 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"N-formyl peptide receptor 2/LX A4 receptor (FPR2/ALX)\nOriginally FPR2 was classified as an FPR receptor due to its activation by the low-affinity endogenous agonist N-formyl methionyl peptide (fMLP) (Ye et al. 1992). The receptor was reclassified as FPR2/ALX, as LXA4 exhibited the highest affinity of all FPR2/ALX endogenous agonists through screening of various receptor ligands using radiolabelled [3H]-LXA4 and subsequent GTPase activity (Fiore et al. 1994; Brink et al. 2003). Binding of LXA4 leads to the stimulation of monocyte chemotaxis, macrophage differentiation, and efferocytosis (Maderna et al. 2010; Maddox and Serhan 1996). LXA4 also reduces the adaptive immune response by reducing memory B cell antibody production and proliferation (Ramon et al. 2014).\nEndogenous and exogenous lipids, peptides, and proteins have been shown to bind and activate FPR2/ALX to produce inflammatory and anti-inflammatory effects (Takano et al. 1997; Cooray et al. 2013). Both the LXs and Rvs families, including LXA4, AT-LXA4 (15-epi-LXA4), RvD1, AT-RvD1 (17-epi-RvD1), and Annexin A1 (ANXA1) activate receptors with high potency. On the other hand, endogenous antagonists, including serum amyloid A (SAA) and cathelicidin (LL-37) have been identified (Bozinovski et al. 2012; Wan et al. 2011).","divisions":[{"label":"title","span":{"begin":0,"end":53}},{"label":"p","span":{"begin":54,"end":771}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"424","span":{"begin":0,"end":27},"obj":"Gene"},{"id":"425","span":{"begin":28,"end":42},"obj":"Gene"},{"id":"426","span":{"begin":44,"end":48},"obj":"Gene"},{"id":"427","span":{"begin":49,"end":52},"obj":"Gene"},{"id":"439","span":{"begin":65,"end":69},"obj":"Gene"},{"id":"440","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"441","span":{"begin":250,"end":254},"obj":"Gene"},{"id":"442","span":{"begin":255,"end":258},"obj":"Gene"},{"id":"443","span":{"begin":306,"end":310},"obj":"Gene"},{"id":"444","span":{"begin":311,"end":314},"obj":"Gene"},{"id":"445","span":{"begin":165,"end":191},"obj":"Chemical"},{"id":"446","span":{"begin":402,"end":404},"obj":"Chemical"},{"id":"447","span":{"begin":493,"end":497},"obj":"Chemical"},{"id":"448","span":{"begin":626,"end":632},"obj":"Chemical"},{"id":"449","span":{"begin":579,"end":592},"obj":"Disease"},{"id":"458","span":{"begin":865,"end":869},"obj":"Gene"},{"id":"459","span":{"begin":870,"end":873},"obj":"Gene"},{"id":"460","span":{"begin":1073,"end":1083},"obj":"Gene"},{"id":"461","span":{"begin":1085,"end":1090},"obj":"Gene"},{"id":"462","span":{"begin":1183,"end":1198},"obj":"Gene"},{"id":"463","span":{"begin":1200,"end":1203},"obj":"Gene"},{"id":"464","span":{"begin":1223,"end":1228},"obj":"Gene"},{"id":"465","span":{"begin":797,"end":803},"obj":"Chemical"}],"attributes":[{"id":"A424","pred":"tao:has_database_id","subj":"424","obj":"Gene:2358"},{"id":"A425","pred":"tao:has_database_id","subj":"425","obj":"Gene:2358"},{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"Gene:2358"},{"id":"A427","pred":"tao:has_database_id","subj":"427","obj":"Gene:84941"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Gene:2358"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Gene:2357"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Gene:2358"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Gene:84941"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Gene:2358"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Gene:84941"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"MESH:D014316"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"MESH:C040527"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"Gene:2358"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"Gene:84941"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"Gene:301"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Gene:301"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Gene:6287"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Gene:6287"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Gene:820"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"MESH:D008055"},{"subj":"424","pred":"source","obj":"LitCovid-PubTator"},{"subj":"425","pred":"source","obj":"LitCovid-PubTator"},{"subj":"426","pred":"source","obj":"LitCovid-PubTator"},{"subj":"427","pred":"source","obj":"LitCovid-PubTator"},{"subj":"439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"443","pred":"source","obj":"LitCovid-PubTator"},{"subj":"444","pred":"source","obj":"LitCovid-PubTator"},{"subj":"445","pred":"source","obj":"LitCovid-PubTator"},{"subj":"446","pred":"source","obj":"LitCovid-PubTator"},{"subj":"447","pred":"source","obj":"LitCovid-PubTator"},{"subj":"448","pred":"source","obj":"LitCovid-PubTator"},{"subj":"449","pred":"source","obj":"LitCovid-PubTator"},{"subj":"458","pred":"source","obj":"LitCovid-PubTator"},{"subj":"459","pred":"source","obj":"LitCovid-PubTator"},{"subj":"460","pred":"source","obj":"LitCovid-PubTator"},{"subj":"461","pred":"source","obj":"LitCovid-PubTator"},{"subj":"462","pred":"source","obj":"LitCovid-PubTator"},{"subj":"463","pred":"source","obj":"LitCovid-PubTator"},{"subj":"464","pred":"source","obj":"LitCovid-PubTator"},{"subj":"465","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T151","span":{"begin":0,"end":53},"obj":"Sentence"},{"id":"T152","span":{"begin":54,"end":209},"obj":"Sentence"},{"id":"T153","span":{"begin":210,"end":216},"obj":"Sentence"},{"id":"T154","span":{"begin":217,"end":455},"obj":"Sentence"},{"id":"T155","span":{"begin":456,"end":474},"obj":"Sentence"},{"id":"T156","span":{"begin":475,"end":481},"obj":"Sentence"},{"id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