> top > docs > PMC:7781431 > spans > 15813-17106 > annotations

PMC:7781431 / 15813-17106 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
424 0-27 Gene denotes N-formyl peptide receptor 2 Gene:2358
425 28-42 Gene denotes LX A4 receptor Gene:2358
426 44-48 Gene denotes FPR2 Gene:2358
427 49-52 Gene denotes ALX Gene:84941
439 65-69 Gene denotes FPR2 Gene:2358
440 193-197 Gene denotes fMLP Gene:2357
441 250-254 Gene denotes FPR2 Gene:2358
442 255-258 Gene denotes ALX Gene:84941
443 306-310 Gene denotes FPR2 Gene:2358
444 311-314 Gene denotes ALX Gene:84941
445 165-191 Chemical denotes N-formyl methionyl peptide
446 402-404 Chemical denotes 3H MESH:D014316
447 493-497 Chemical denotes LXA4 MESH:C040527
448 626-632 Chemical denotes Serhan
449 579-592 Disease denotes efferocytosis
458 865-869 Gene denotes FPR2 Gene:2358
459 870-873 Gene denotes ALX Gene:84941
460 1073-1083 Gene denotes Annexin A1 Gene:301
461 1085-1090 Gene denotes ANXA1 Gene:301
462 1183-1198 Gene denotes serum amyloid A Gene:6287
463 1200-1203 Gene denotes SAA Gene:6287
464 1223-1228 Gene denotes LL-37 Gene:820
465 797-803 Chemical denotes lipids MESH:D008055

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T151 0-53 Sentence denotes N-formyl peptide receptor 2/LX A4 receptor (FPR2/ALX)
T152 54-209 Sentence denotes Originally FPR2 was classified as an FPR receptor due to its activation by the low-affinity endogenous agonist N-formyl methionyl peptide (fMLP) (Ye et al.
T153 210-216 Sentence denotes 1992).
T154 217-455 Sentence denotes The receptor was reclassified as FPR2/ALX, as LXA4 exhibited the highest affinity of all FPR2/ALX endogenous agonists through screening of various receptor ligands using radiolabelled [3H]-LXA4 and subsequent GTPase activity (Fiore et al.
T155 456-474 Sentence denotes 1994; Brink et al.
T156 475-481 Sentence denotes 2003).
T157 482-608 Sentence denotes Binding of LXA4 leads to the stimulation of monocyte chemotaxis, macrophage differentiation, and efferocytosis (Maderna et al.
T158 609-639 Sentence denotes 2010; Maddox and Serhan 1996).
T159 640-764 Sentence denotes LXA4 also reduces the adaptive immune response by reducing memory B cell antibody production and proliferation (Ramon et al.
T160 765-771 Sentence denotes 2014).
T161 772-942 Sentence denotes Endogenous and exogenous lipids, peptides, and proteins have been shown to bind and activate FPR2/ALX to produce inflammatory and anti-inflammatory effects (Takano et al.
T162 943-962 Sentence denotes 1997; Cooray et al.
T163 963-969 Sentence denotes 2013).
T164 970-1129 Sentence denotes Both the LXs and Rvs families, including LXA4, AT-LXA4 (15-epi-LXA4), RvD1, AT-RvD1 (17-epi-RvD1), and Annexin A1 (ANXA1) activate receptors with high potency.
T165 1130-1269 Sentence denotes On the other hand, endogenous antagonists, including serum amyloid A (SAA) and cathelicidin (LL-37) have been identified (Bozinovski et al.
T166 1270-1286 Sentence denotes 2012; Wan et al.
T167 1287-1293 Sentence denotes 2011).