PMC:7781431 / 12531-13260 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7781431","sourcedb":"PMC","sourceid":"7781431","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7781431","text":"Protectin D1 (PD1), also known as neuroprotectin D1 (NPD1), is derived from DHA. DHA is a component of fish oil and the most important omega-3 PUFA. Like other members of PUFA metabolites specialized pro-resolving mediators class, PD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective biological activities (Hong et al. 2003; Bazan 2007). PD1 accumulates in the ipsilateral hemisphere of the brain after focal ischemia and has been shown to take part in wound healing and neuroprotection. 15-LOX can acts 17S-HpDHA to produce the isomers of PD1, 10S, 17S-diHDHA (PDx), which also have pro-resolving activity. PD1 production peaks at 12 hours in a zymosan A-induced rat peritonitis model (Bannenberg et al. 2005).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"368","span":{"begin":143,"end":147},"obj":"Gene"},{"id":"369","span":{"begin":171,"end":175},"obj":"Gene"},{"id":"370","span":{"begin":682,"end":685},"obj":"Species"},{"id":"371","span":{"begin":76,"end":79},"obj":"Chemical"},{"id":"372","span":{"begin":81,"end":84},"obj":"Chemical"},{"id":"373","span":{"begin":103,"end":111},"obj":"Chemical"},{"id":"374","span":{"begin":563,"end":578},"obj":"Chemical"},{"id":"375","span":{"begin":427,"end":435},"obj":"Disease"}],"attributes":[{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"Gene:9933"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"Gene:9933"},{"id":"A370","pred":"tao:has_database_id","subj":"370","obj":"Tax:10116"},{"id":"A371","pred":"tao:has_database_id","subj":"371","obj":"MESH:D004281"},{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"MESH:D004281"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"MESH:D005395"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"MESH:D007511"},{"subj":"368","pred":"source","obj":"LitCovid-PubTator"},{"subj":"369","pred":"source","obj":"LitCovid-PubTator"},{"subj":"370","pred":"source","obj":"LitCovid-PubTator"},{"subj":"371","pred":"source","obj":"LitCovid-PubTator"},{"subj":"372","pred":"source","obj":"LitCovid-PubTator"},{"subj":"373","pred":"source","obj":"LitCovid-PubTator"},{"subj":"374","pred":"source","obj":"LitCovid-PubTator"},{"subj":"375","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T10","span":{"begin":686,"end":697},"obj":"Phenotype"}],"attributes":[{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002586"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T109","span":{"begin":0,"end":80},"obj":"Sentence"},{"id":"T110","span":{"begin":81,"end":148},"obj":"Sentence"},{"id":"T111","span":{"begin":149,"end":336},"obj":"Sentence"},{"id":"T112","span":{"begin":337,"end":355},"obj":"Sentence"},{"id":"T113","span":{"begin":356,"end":505},"obj":"Sentence"},{"id":"T114","span":{"begin":506,"end":625},"obj":"Sentence"},{"id":"T115","span":{"begin":626,"end":722},"obj":"Sentence"},{"id":"T116","span":{"begin":723,"end":729},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T109","pred":"source","obj":"LitCovid-sentences"},{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"},{"subj":"T112","pred":"source","obj":"LitCovid-sentences"},{"subj":"T113","pred":"source","obj":"LitCovid-sentences"},{"subj":"T114","pred":"source","obj":"LitCovid-sentences"},{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec9e93","default":true},{"id":"LitCovid-PD-HP","color":"#93a2ec"},{"id":"LitCovid-sentences","color":"#bcec93"}]}]}}