Protectin D1 (PD1), also known as neuroprotectin D1 (NPD1), is derived from DHA. DHA is a component of fish oil and the most important omega-3 PUFA. Like other members of PUFA metabolites specialized pro-resolving mediators class, PD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective biological activities (Hong et al. 2003; Bazan 2007). PD1 accumulates in the ipsilateral hemisphere of the brain after focal ischemia and has been shown to take part in wound healing and neuroprotection. 15-LOX can acts 17S-HpDHA to produce the isomers of PD1, 10S, 17S-diHDHA (PDx), which also have pro-resolving activity. PD1 production peaks at 12 hours in a zymosan A-induced rat peritonitis model (Bannenberg et al. 2005).