PMC:7755033 / 70866-71258 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":" written in bold in Tables 9 and 10. As far as viral PL-pro and human ACE2 are concerned, WS phytoconstituents displayed allosteric binding to these enzymes.\nOn the other hand, withanolide A displayed strong binding to SARS-CoV spike glycoprotein (Table 6; BE: −9.78 kcal/mol, Kd: 67.23 nM), SARS-CoV-2 spike glycoprotein (Table 7; BE: −7.18 kcal/mol, Kd: 5.48 µM), SARS-CoV 3CL-pro main prot","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"916","span":{"begin":53,"end":59},"obj":"Gene"},{"id":"917","span":{"begin":70,"end":74},"obj":"Gene"},{"id":"924","span":{"begin":64,"end":69},"obj":"Species"},{"id":"925","span":{"begin":90,"end":92},"obj":"Species"},{"id":"958","span":{"begin":303,"end":308},"obj":"Gene"},{"id":"960","span":{"begin":228,"end":233},"obj":"Gene"},{"id":"961","span":{"begin":219,"end":227},"obj":"Species"},{"id":"962","span":{"begin":292,"end":302},"obj":"Species"},{"id":"963","span":{"begin":366,"end":374},"obj":"Species"}],"attributes":[{"id":"A916","pred":"tao:has_database_id","subj":"916","obj":"Gene:43740578"},{"id":"A917","pred":"tao:has_database_id","subj":"917","obj":"Gene:59272"},{"id":"A924","pred":"tao:has_database_id","subj":"924","obj":"Tax:9606"},{"id":"A925","pred":"tao:has_database_id","subj":"925","obj":"Tax:126910"},{"id":"A958","pred":"tao:has_database_id","subj":"958","obj":"Gene:43740568"},{"id":"A960","pred":"tao:has_database_id","subj":"960","obj":"Gene:43740568"},{"id":"A961","pred":"tao:has_database_id","subj":"961","obj":"Tax:694009"},{"id":"A962","pred":"tao:has_database_id","subj":"962","obj":"Tax:2697049"},{"id":"A963","pred":"tao:has_database_id","subj":"963","obj":"Tax:694009"},{"subj":"916","pred":"source","obj":"LitCovid-PubTator"},{"subj":"917","pred":"source","obj":"LitCovid-PubTator"},{"subj":"924","pred":"source","obj":"LitCovid-PubTator"},{"subj":"925","pred":"source","obj":"LitCovid-PubTator"},{"subj":"958","pred":"source","obj":"LitCovid-PubTator"},{"subj":"960","pred":"source","obj":"LitCovid-PubTator"},{"subj":"961","pred":"source","obj":"LitCovid-PubTator"},{"subj":"962","pred":"source","obj":"LitCovid-PubTator"},{"subj":"963","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T623","span":{"begin":37,"end":157},"obj":"Sentence"},{"id":"T624","span":{"begin":158,"end":280},"obj":"Sentence"},{"id":"T625","span":{"begin":281,"end":355},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T623","pred":"source","obj":"LitCovid-sentences"},{"subj":"T624","pred":"source","obj":"LitCovid-sentences"},{"subj":"T625","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93e1","default":true},{"id":"LitCovid-sentences","color":"#93ecdd"}]}]}}