PMC:7755033 / 39311-39791 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7755033","sourcedb":"PMC","sourceid":"7755033","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7755033","text":"sion 4.2.6 program revealed that the binding affinities of the WS phytoconstituents for the human ACE2 receptor decreased in the order withanolide B \u003e withanolide A \u003e withanolide E \u003e viscosalactone B \u003e withaferin A \u003e anaferine \u003e withanolide D \u003e withanone \u003e withasomnine. Withanolide B exhibited a 1000× stronger binding to human ACE2 receptor (Table 5; BE: −10.21 kcal/mol, Kd: 32.78 nM) as compared to standard reference drugs, arbidol (Table 5; BE: −6.69 kcal/mol, Kd: 12.47 µM)","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"754","span":{"begin":98,"end":102},"obj":"Gene"},{"id":"755","span":{"begin":329,"end":333},"obj":"Gene"},{"id":"767","span":{"begin":92,"end":97},"obj":"Species"},{"id":"768","span":{"begin":323,"end":328},"obj":"Species"},{"id":"774","span":{"begin":63,"end":65},"obj":"Species"},{"id":"776","span":{"begin":135,"end":146},"obj":"Chemical"},{"id":"777","span":{"begin":151,"end":162},"obj":"Chemical"},{"id":"778","span":{"begin":167,"end":178},"obj":"Chemical"},{"id":"779","span":{"begin":183,"end":197},"obj":"Chemical"},{"id":"780","span":{"begin":202,"end":212},"obj":"Chemical"},{"id":"781","span":{"begin":217,"end":226},"obj":"Chemical"},{"id":"782","span":{"begin":229,"end":240},"obj":"Chemical"},{"id":"783","span":{"begin":245,"end":254},"obj":"Chemical"},{"id":"784","span":{"begin":257,"end":269},"obj":"Chemical"},{"id":"785","span":{"begin":353,"end":355},"obj":"Chemical"},{"id":"786","span":{"begin":429,"end":436},"obj":"Chemical"},{"id":"787","span":{"begin":447,"end":449},"obj":"Chemical"}],"attributes":[{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"Gene:59272"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"Gene:59272"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"Tax:9606"},{"id":"A768","pred":"tao:has_database_id","subj":"768","obj":"Tax:9606"},{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"Tax:126910"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:D054358"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:D054358"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"MESH:D054358"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"MESH:D054358"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"MESH:C560597"},{"id":"A784","pred":"tao:has_database_id","subj":"784","obj":"MESH:C568582"},{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"MESH:C086979"},{"subj":"754","pred":"source","obj":"LitCovid-PubTator"},{"subj":"755","pred":"source","obj":"LitCovid-PubTator"},{"subj":"767","pred":"source","obj":"LitCovid-PubTator"},{"subj":"768","pred":"source","obj":"LitCovid-PubTator"},{"subj":"774","pred":"source","obj":"LitCovid-PubTator"},{"subj":"776","pred":"source","obj":"LitCovid-PubTator"},{"subj":"777","pred":"source","obj":"LitCovid-PubTator"},{"subj":"778","pred":"source","obj":"LitCovid-PubTator"},{"subj":"779","pred":"source","obj":"LitCovid-PubTator"},{"subj":"780","pred":"source","obj":"LitCovid-PubTator"},{"subj":"781","pred":"source","obj":"LitCovid-PubTator"},{"subj":"782","pred":"source","obj":"LitCovid-PubTator"},{"subj":"783","pred":"source","obj":"LitCovid-PubTator"},{"subj":"784","pred":"source","obj":"LitCovid-PubTator"},{"subj":"785","pred":"source","obj":"LitCovid-PubTator"},{"subj":"786","pred":"source","obj":"LitCovid-PubTator"},{"subj":"787","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T406","span":{"begin":271,"end":377},"obj":"Sentence"},{"id":"T407","span":{"begin":378,"end":470},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T406","pred":"source","obj":"LitCovid-sentences"},{"subj":"T407","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#a193ec","default":true},{"id":"LitCovid-sentences","color":"#9fec93"}]}]}}