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PMC:7736111 / 89155-91393 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T20 1090-1110 Phenotype denotes autoimmune condition http://purl.obolibrary.org/obo/HP_0002960

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2209 1841-1846 Gene denotes CD138 Gene:6382
2210 487-495 Species denotes patients Tax:9606
2211 1193-1201 Species denotes patients Tax:9606
2212 1603-1611 Species denotes patients Tax:9606
2213 1289-1299 Species denotes SARS-CoV-2 Tax:2697049
2214 1686-1696 Species denotes SARS-CoV-2 Tax:2697049
2215 159-167 Disease denotes COVID-19 MESH:C000657245
2216 1178-1192 Disease denotes critically ill MESH:D016638
2217 1423-1437 Disease denotes critically ill MESH:D016638

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T523 0-185 Sentence denotes Deep immune profiling integrated with computational approach revealed intricate relations of B cell response with clinical parameters at various stages of the COVID-19 disease severity.
T524 186-298 Sentence denotes These cells express proliferation (Ki67+), differentiation (CD27+ CD38+), as well as exhaustion markers (PD-1+).
T525 299-466 Sentence denotes More robust expression of these markers was observed in severe cases compared to mild-moderate, with an overall decrease in memory B cell number (Mathew et al., 2020).
T526 467-621 Sentence denotes Further, 70% of the patients reported have IgG and IgM S protein-specific antibodies, suggesting activation status of the antibody-secreting plasmablasts.
T527 622-793 Sentence denotes Thus, this study shows that B cells, in severe cases, display concomitant activation and exhaustion markers, while mild cases or healthy controls showed a normal response.
T528 794-890 Sentence denotes However, how this activated status of B cells had an impact on disease severity was not studied.
T529 891-1111 Sentence denotes By looking at the alleged relationship of activated B cells with disease severity, Woodruff et al. (2020) showed robust activation status of extrafollicular B cells which resembled their behavior in autoimmune condition.
T530 1112-1353 Sentence denotes The activation status of these cells was found more pronounced in critically ill patients (n = 10) than non-critical (n = 7) and healthy control (n = 17), which correlated with SARS-CoV-2-specific antibody production and disease progression.
T531 1354-1572 Sentence denotes Further, an increase in antibody-secreting cells (ASCs) was found in critically ill cases compared to non-severe cases along with an increase in S protein-specific antibodies, probably with a non-neutralizing property.
T532 1573-1783 Sentence denotes This study shows that in some patients with a critical disease condition, robust B cell response and presence of SARS-CoV-2 antigen-specific antibodies may be associated with worsening of the disease condition.
T533 1784-1871 Sentence denotes The ASCs were identified as the population of cells with CD138+ and CD21low expression.
T534 1872-1960 Sentence denotes However, no comparison was drawn between various age groups concerning disease severity.
T535 1961-2097 Sentence denotes While across studies, B cell activation is apparent in severe cases, it is subsequently associated with a sharp decline in their number.
T536 2098-2238 Sentence denotes Various mechanisms may be responsible for this decline, among which B cell exhaustion is one, but still poorly understood (Yi et al., 2010).