PMC:7736111 / 74972-75779
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Hyperinflammatory condition mediated by cytokines, chemokines and associated proinflammatory molecules which are secreted by both innate and adaptive immune cells. However, during COVID-19, the relative contribution of adaptive immune cells towards proinflammatory molecules is still emerging, while the published studies suggest a complex interplay. Profiling of 21 cytokines and chemokines in 39 patients and 24 healthy controls revealed increased levels of TH1 specific cytokines like IFN-γ, IL-2, and IL-12, and TH17 specific IL-17 in peripheral blood. In comparison to the mild cases (n = 19), patients with severe disease (n = 10) condition had increased levels of these cytokines. The limitation of this study was that the median age of severe cases was higher than in mild cases (Song et al., 2020).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"1845","span":{"begin":460,"end":463},"obj":"Gene"},{"id":"1846","span":{"begin":488,"end":493},"obj":"Gene"},{"id":"1847","span":{"begin":495,"end":499},"obj":"Gene"},{"id":"1848","span":{"begin":530,"end":535},"obj":"Gene"},{"id":"1849","span":{"begin":398,"end":406},"obj":"Species"},{"id":"1850","span":{"begin":599,"end":607},"obj":"Species"},{"id":"1851","span":{"begin":180,"end":188},"obj":"Disease"}],"attributes":[{"id":"A1845","pred":"tao:has_database_id","subj":"1845","obj":"Gene:51497"},{"id":"A1846","pred":"tao:has_database_id","subj":"1846","obj":"Gene:3458"},{"id":"A1847","pred":"tao:has_database_id","subj":"1847","obj":"Gene:3558"},{"id":"A1848","pred":"tao:has_database_id","subj":"1848","obj":"Gene:3605"},{"id":"A1849","pred":"tao:has_database_id","subj":"1849","obj":"Tax:9606"},{"id":"A1850","pred":"tao:has_database_id","subj":"1850","obj":"Tax:9606"},{"id":"A1851","pred":"tao:has_database_id","subj":"1851","obj":"MESH:C000657245"},{"subj":"1845","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1846","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1847","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1848","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1849","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1850","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1851","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T440","span":{"begin":0,"end":163},"obj":"Sentence"},{"id":"T441","span":{"begin":164,"end":350},"obj":"Sentence"},{"id":"T442","span":{"begin":351,"end":556},"obj":"Sentence"},{"id":"T443","span":{"begin":557,"end":687},"obj":"Sentence"},{"id":"T444","span":{"begin":688,"end":807},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T440","pred":"source","obj":"LitCovid-sentences"},{"subj":"T441","pred":"source","obj":"LitCovid-sentences"},{"subj":"T442","pred":"source","obj":"LitCovid-sentences"},{"subj":"T443","pred":"source","obj":"LitCovid-sentences"},{"subj":"T444","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#9dec93","default":true},{"id":"LitCovid-sentences","color":"#ec93b7"}]}]}}