PMC:7736111 / 28956-30188 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Based on the recent clinical data on COVID-19 patients, we can infer that mild/moderate patients should possess optimal early IFN response. Whereas, weak or delayed IFN response may be the tipping point in eliciting hyperinflammatory state, allowing extensive viral propagation. Previous studies in animal models have shown that early IFN response was the determining factor in inhibiting viral propagation and attenuating disease condition (Channappanavar et al., 2016). In line with this, a recent study has shown that COVID-19 patients with mild/moderate conditions possess functional type I and type III IFN response. Specifically, patients with mild/moderate symptoms have adequate levels of IFNA transcript and protein in the plasma. The presence of detectable IFN levels in these subsets of patients was also associated with the expression of downstream signaling receptors and molecules like IFNAR1, JAK1, and TYK2, suggesting functional IFN response. However, no IFNB mRNA or protein was detected, while optimal levels of IFN-λ were detected both at the mRNA and protein levels. Expectedly, the levels of type I and type III IFNs positively correlated with the viral load and severity of the disease (Hadjadj et al., 2020).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"759","span":{"begin":165,"end":168},"obj":"Gene"},{"id":"760","span":{"begin":335,"end":338},"obj":"Gene"},{"id":"761","span":{"begin":697,"end":701},"obj":"Gene"},{"id":"762","span":{"begin":767,"end":770},"obj":"Gene"},{"id":"763","span":{"begin":900,"end":906},"obj":"Gene"},{"id":"764","span":{"begin":908,"end":912},"obj":"Gene"},{"id":"765","span":{"begin":918,"end":922},"obj":"Gene"},{"id":"766","span":{"begin":946,"end":949},"obj":"Gene"},{"id":"767","span":{"begin":972,"end":976},"obj":"Gene"},{"id":"768","span":{"begin":1031,"end":1034},"obj":"Gene"},{"id":"769","span":{"begin":126,"end":129},"obj":"Gene"},{"id":"770","span":{"begin":46,"end":54},"obj":"Species"},{"id":"771","span":{"begin":88,"end":96},"obj":"Species"},{"id":"772","span":{"begin":530,"end":538},"obj":"Species"},{"id":"773","span":{"begin":636,"end":644},"obj":"Species"},{"id":"774","span":{"begin":798,"end":806},"obj":"Species"},{"id":"775","span":{"begin":608,"end":611},"obj":"Gene"},{"id":"776","span":{"begin":37,"end":45},"obj":"Disease"},{"id":"777","span":{"begin":521,"end":529},"obj":"Disease"}],"attributes":[{"id":"A759","pred":"tao:has_database_id","subj":"759","obj":"Gene:3439"},{"id":"A760","pred":"tao:has_database_id","subj":"760","obj":"Gene:3439"},{"id":"A761","pred":"tao:has_database_id","subj":"761","obj":"Gene:3439"},{"id":"A762","pred":"tao:has_database_id","subj":"762","obj":"Gene:3439"},{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"Gene:3454"},{"id":"A764","pred":"tao:has_database_id","subj":"764","obj":"Gene:3716"},{"id":"A765","pred":"tao:has_database_id","subj":"765","obj":"Gene:7297"},{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"Gene:3439"},{"id":"A767","pred":"tao:has_database_id","subj":"767","obj":"Gene:3456"},{"id":"A768","pred":"tao:has_database_id","subj":"768","obj":"Gene:3439"},{"id":"A769","pred":"tao:has_database_id","subj":"769","obj":"Gene:3439"},{"id":"A770","pred":"tao:has_database_id","subj":"770","obj":"Tax:9606"},{"id":"A771","pred":"tao:has_database_id","subj":"771","obj":"Tax:9606"},{"id":"A772","pred":"tao:has_database_id","subj":"772","obj":"Tax:9606"},{"id":"A773","pred":"tao:has_database_id","subj":"773","obj":"Tax:9606"},{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"Tax:9606"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"Gene:3439"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:C000657245"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:C000657245"},{"subj":"759","pred":"source","obj":"LitCovid-PubTator"},{"subj":"760","pred":"source","obj":"LitCovid-PubTator"},{"subj":"761","pred":"source","obj":"LitCovid-PubTator"},{"subj":"762","pred":"source","obj":"LitCovid-PubTator"},{"subj":"763","pred":"source","obj":"LitCovid-PubTator"},{"subj":"764","pred":"source","obj":"LitCovid-PubTator"},{"subj":"765","pred":"source","obj":"LitCovid-PubTator"},{"subj":"766","pred":"source","obj":"LitCovid-PubTator"},{"subj":"767","pred":"source","obj":"LitCovid-PubTator"},{"subj":"768","pred":"source","obj":"LitCovid-PubTator"},{"subj":"769","pred":"source","obj":"LitCovid-PubTator"},{"subj":"770","pred":"source","obj":"LitCovid-PubTator"},{"subj":"771","pred":"source","obj":"LitCovid-PubTator"},{"subj":"772","pred":"source","obj":"LitCovid-PubTator"},{"subj":"773","pred":"source","obj":"LitCovid-PubTator"},{"subj":"774","pred":"source","obj":"LitCovid-PubTator"},{"subj":"775","pred":"source","obj":"LitCovid-PubTator"},{"subj":"776","pred":"source","obj":"LitCovid-PubTator"},{"subj":"777","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T168","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T169","span":{"begin":140,"end":278},"obj":"Sentence"},{"id":"T170","span":{"begin":279,"end":471},"obj":"Sentence"},{"id":"T171","span":{"begin":472,"end":621},"obj":"Sentence"},{"id":"T172","span":{"begin":622,"end":739},"obj":"Sentence"},{"id":"T173","span":{"begin":740,"end":959},"obj":"Sentence"},{"id":"T174","span":{"begin":960,"end":1087},"obj":"Sentence"},{"id":"T175","span":{"begin":1088,"end":1232},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T168","pred":"source","obj":"LitCovid-sentences"},{"subj":"T169","pred":"source","obj":"LitCovid-sentences"},{"subj":"T170","pred":"source","obj":"LitCovid-sentences"},{"subj":"T171","pred":"source","obj":"LitCovid-sentences"},{"subj":"T172","pred":"source","obj":"LitCovid-sentences"},{"subj":"T173","pred":"source","obj":"LitCovid-sentences"},{"subj":"T174","pred":"source","obj":"LitCovid-sentences"},{"su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