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PMC:7736111 / 28956-30188 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
759 165-168 Gene denotes IFN Gene:3439
760 335-338 Gene denotes IFN Gene:3439
761 697-701 Gene denotes IFNA Gene:3439
762 767-770 Gene denotes IFN Gene:3439
763 900-906 Gene denotes IFNAR1 Gene:3454
764 908-912 Gene denotes JAK1 Gene:3716
765 918-922 Gene denotes TYK2 Gene:7297
766 946-949 Gene denotes IFN Gene:3439
767 972-976 Gene denotes IFNB Gene:3456
768 1031-1034 Gene denotes IFN Gene:3439
769 126-129 Gene denotes IFN Gene:3439
770 46-54 Species denotes patients Tax:9606
771 88-96 Species denotes patients Tax:9606
772 530-538 Species denotes patients Tax:9606
773 636-644 Species denotes patients Tax:9606
774 798-806 Species denotes patients Tax:9606
775 608-611 Gene denotes IFN Gene:3439
776 37-45 Disease denotes COVID-19 MESH:C000657245
777 521-529 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T168 0-139 Sentence denotes Based on the recent clinical data on COVID-19 patients, we can infer that mild/moderate patients should possess optimal early IFN response.
T169 140-278 Sentence denotes Whereas, weak or delayed IFN response may be the tipping point in eliciting hyperinflammatory state, allowing extensive viral propagation.
T170 279-471 Sentence denotes Previous studies in animal models have shown that early IFN response was the determining factor in inhibiting viral propagation and attenuating disease condition (Channappanavar et al., 2016).
T171 472-621 Sentence denotes In line with this, a recent study has shown that COVID-19 patients with mild/moderate conditions possess functional type I and type III IFN response.
T172 622-739 Sentence denotes Specifically, patients with mild/moderate symptoms have adequate levels of IFNA transcript and protein in the plasma.
T173 740-959 Sentence denotes The presence of detectable IFN levels in these subsets of patients was also associated with the expression of downstream signaling receptors and molecules like IFNAR1, JAK1, and TYK2, suggesting functional IFN response.
T174 960-1087 Sentence denotes However, no IFNB mRNA or protein was detected, while optimal levels of IFN-λ were detected both at the mRNA and protein levels.
T175 1088-1232 Sentence denotes Expectedly, the levels of type I and type III IFNs positively correlated with the viral load and severity of the disease (Hadjadj et al., 2020).