PMC:7736111 / 28123-28955 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Recent in vitro studies point to a more robust IFN response generated by SARS-CoV-2 compared to its predecessor. Epithelial cells infected with SARS-CoV-2 displayed better IFN response than cells infected with SARS-CoV. This IFN response was STAT1 phosphorylation-dependent with subsequent expression of antiviral ISGs (Lokugamage et al., 2020). In line with these in vitro findings, transcriptome data from bronchial alveolar lavage fluid (BALF) taken from 8 COVID-19 patients revealed extensive upregulation of about 83 ISGs, suggesting robust IFN response generated against SARS-CoV-2 (Zhou Z. et al., 2020). Further, a study by Ziegler et al. 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