PMC:7736111 / 24972-25886 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Interestingly, the results, that ORF3a of SARS-CoV-2 induces relatively lower apoptosis in several cell lines as compared to SARS-CoV, suggesting that this mechanism could provide an early advantage for the propagation of SARS-CoV-2. Further, the proteome map of SARS-CoV-2 predicted interaction of Nsp12 with RIPK1, suggesting that this viral protein may also implicate in regulating host cell apoptotic and necroptotic cell death (Gordon et al., 2020). However, a study on 25 cell lines in culture showed SARS-CoV-2 exhibiting cytopathic effect on only two cells, indicating that the differences could exist between these two related viruses in their property to interfere with host cell death pathways (Chu et al., 2020). Thus, more comprehensive studies are needed to provide better molecular insights by which SARS-CoV-2 modulates host cell death pathways, which may also open new opportunities for treatment.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"664","span":{"begin":33,"end":38},"obj":"Gene"},{"id":"665","span":{"begin":310,"end":315},"obj":"Gene"},{"id":"666","span":{"begin":42,"end":52},"obj":"Species"},{"id":"667","span":{"begin":125,"end":133},"obj":"Species"},{"id":"668","span":{"begin":222,"end":232},"obj":"Species"},{"id":"669","span":{"begin":263,"end":273},"obj":"Species"},{"id":"670","span":{"begin":507,"end":517},"obj":"Species"},{"id":"671","span":{"begin":815,"end":825},"obj":"Species"}],"attributes":[{"id":"A664","pred":"tao:has_database_id","subj":"664","obj":"Gene:43740569"},{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"Gene:8737"},{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"Tax:2697049"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"Tax:694009"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"Tax:2697049"},{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"Tax:2697049"},{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"Tax:2697049"},{"id":"A671","pred":"tao:has_database_id","subj":"671","obj":"Tax:2697049"},{"subj":"664","pred":"source","obj":"LitCovid-PubTator"},{"subj":"665","pred":"source","obj":"LitCovid-PubTator"},{"subj":"666","pred":"source","obj":"LitCovid-PubTator"},{"subj":"667","pred":"source","obj":"LitCovid-PubTator"},{"subj":"668","pred":"source","obj":"LitCovid-PubTator"},{"subj":"669","pred":"source","obj":"LitCovid-PubTator"},{"subj":"670","pred":"source","obj":"LitCovid-PubTator"},{"subj":"671","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T145","span":{"begin":0,"end":233},"obj":"Sentence"},{"id":"T146","span":{"begin":234,"end":454},"obj":"Sentence"},{"id":"T147","span":{"begin":455,"end":724},"obj":"Sentence"},{"id":"T148","span":{"begin":725,"end":914},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T145","pred":"source","obj":"LitCovid-sentences"},{"subj":"T146","pred":"source","obj":"LitCovid-sentences"},{"subj":"T147","pred":"source","obj":"LitCovid-sentences"},{"subj":"T148","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93d8","default":true},{"id":"LitCovid-sentences","color":"#93ece6"}]}]}}