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PMC:7736111 / 24972-25886 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
664 33-38 Gene denotes ORF3a Gene:43740569
665 310-315 Gene denotes RIPK1 Gene:8737
666 42-52 Species denotes SARS-CoV-2 Tax:2697049
667 125-133 Species denotes SARS-CoV Tax:694009
668 222-232 Species denotes SARS-CoV-2 Tax:2697049
669 263-273 Species denotes SARS-CoV-2 Tax:2697049
670 507-517 Species denotes SARS-CoV-2 Tax:2697049
671 815-825 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T145 0-233 Sentence denotes Interestingly, the results, that ORF3a of SARS-CoV-2 induces relatively lower apoptosis in several cell lines as compared to SARS-CoV, suggesting that this mechanism could provide an early advantage for the propagation of SARS-CoV-2.
T146 234-454 Sentence denotes Further, the proteome map of SARS-CoV-2 predicted interaction of Nsp12 with RIPK1, suggesting that this viral protein may also implicate in regulating host cell apoptotic and necroptotic cell death (Gordon et al., 2020).
T147 455-724 Sentence denotes However, a study on 25 cell lines in culture showed SARS-CoV-2 exhibiting cytopathic effect on only two cells, indicating that the differences could exist between these two related viruses in their property to interfere with host cell death pathways (Chu et al., 2020).
T148 725-914 Sentence denotes Thus, more comprehensive studies are needed to provide better molecular insights by which SARS-CoV-2 modulates host cell death pathways, which may also open new opportunities for treatment.