PMC:7736111 / 109038-109935 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7736111","sourcedb":"PMC","sourceid":"7736111","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7736111","text":"Immune profiles of COVID-19 patients show adequate levels of chemokines and cytokines involved in the maintenance of T and B cell phenotypes (Yang X. et al., 2020; Yang Y. et al., 2020). Chemokines and cytokines responsible for CD8+ T cells priming and chemotaxis were also detected in the patients. Similarly, cytokines responsible for B cell activation and proliferation signals were sufficiently present, thus excluding the possibility that lymphocytopenia may be a result of impaired activation signals or chemokine signaling. Interestingly, a recent study suggests that severely ill COVID-19 patients had lower levels of activated (CD11a+) and terminally differentiated (CD57+) peripheral blood CD4+ and CD8+ T cells (which are also S-protein reactive). The decline in the number of these cells can attribute to their concomitant migration to the infected regions under inflammatory response.","tracks":[{"project":"LitCovid-PD-HP","denotations":[{"id":"T27","span":{"begin":444,"end":459},"obj":"Phenotype"}],"attributes":[{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2509","span":{"begin":228,"end":231},"obj":"Gene"},{"id":"2510","span":{"begin":637,"end":642},"obj":"Gene"},{"id":"2511","span":{"begin":700,"end":703},"obj":"Gene"},{"id":"2512","span":{"begin":709,"end":712},"obj":"Gene"},{"id":"2513","span":{"begin":28,"end":36},"obj":"Species"},{"id":"2514","span":{"begin":290,"end":298},"obj":"Species"},{"id":"2515","span":{"begin":597,"end":605},"obj":"Species"},{"id":"2516","span":{"begin":19,"end":27},"obj":"Disease"},{"id":"2517","span":{"begin":444,"end":459},"obj":"Disease"},{"id":"2518","span":{"begin":588,"end":596},"obj":"Disease"},{"id":"2519","span":{"begin":852,"end":860},"obj":"Disease"}],"attributes":[{"id":"A2509","pred":"tao:has_database_id","subj":"2509","obj":"Gene:925"},{"id":"A2510","pred":"tao:has_database_id","subj":"2510","obj":"Gene:3683"},{"id":"A2511","pred":"tao:has_database_id","subj":"2511","obj":"Gene:920"},{"id":"A2512","pred":"tao:has_database_id","subj":"2512","obj":"Gene:925"},{"id":"A2513","pred":"tao:has_database_id","subj":"2513","obj":"Tax:9606"},{"id":"A2514","pred":"tao:has_database_id","subj":"2514","obj":"Tax:9606"},{"id":"A2515","pred":"tao:has_database_id","subj":"2515","obj":"Tax:9606"},{"id":"A2516","pred":"tao:has_database_id","subj":"2516","obj":"MESH:C000657245"},{"id":"A2517","pred":"tao:has_database_id","subj":"2517","obj":"MESH:D008231"},{"id":"A2518","pred":"tao:has_database_id","subj":"2518","obj":"MESH:C000657245"},{"id":"A2519","pred":"tao:has_database_id","subj":"2519","obj":"MESH:D007239"},{"subj":"2509","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2510","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2511","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2512","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2513","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2514","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2515","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2516","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2517","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2518","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2519","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T644","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T645","span":{"begin":187,"end":299},"obj":"Sentence"},{"id":"T646","span":{"begin":300,"end":530},"obj":"Sentence"},{"id":"T647","span":{"begin":531,"end":758},"obj":"Sentence"},{"id":"T648","span":{"begin":759,"end":897},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T644","pred":"source","obj":"LitCovid-sentences"},{"subj":"T645","pred":"source","obj":"LitCovid-sentences"},{"subj":"T646","pred":"source","obj":"LitCovid-sentences"},{"subj":"T647","pred":"source","obj":"LitCovid-sentences"},{"subj":"T648","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-HP","color":"#e6ec93","default":true},{"id":"LitCovid-PubTator","color":"#d793ec"},{"id":"LitCovid-sentences","color":"#93ecbd"}]}]}}